Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)
1_MAQQR 6_ ALPQS 11_ KETLL 16_ QSYNK 21_ RLKDD 26_ IKSIM 31_ DNFTE 36_ IIKTA 41_ KIEDE 46_ TQVSR 51_ ATQGE 56_ QDNYE 61_ MHVRA 66_ ANIVR 71_ AGESL 76_ MKLVS 81_ DLKQF 86_ LILND 91_ FPSVN 96_ EAIDQ 101_ RNQQL 106_ RTLQE 111_ ECDRK 116_ LITLR 121_ DEISI 126_ DLYEL 131_ EEEYY 136_ SSSSS 141_ LCEAN 146_ DLPLC 151_ EAYGR 156_ LDLDT 161_ DSADG 166_ LSAPL 171_ LASPE 176_ PSAGP 181_ LQVAA 186_ PAHSH 191_AGGPG
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors