Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)
1_MAAGA 6_ GTAGP 11_ ASGPG 16_ VVRDP 21_ AASQP 26_ RKRPG 31_ REGGE 36_ GARRS 41_ DTMAG 46_ GGGSS 51_ DGSGR 56_ AAGRR 61_ ASRSS 66_ GRARR 71_ GRHEP 76_ GLGGP 81_ AERGA 86_ GEARL 91_ EEAVN 96_ RWVLK 101_ FYFHE 106_ ALRAF 111_ RGSRY 116_ GDFRQ 121_ IRDIM 126_ QALLV 131_ RPLGK 136_ EHTVS 141_ RLLRV 146_ MQCLS 151_ RIEEG 156_ ENLDC 161_ SFDME 166_ AELTP 171_ LESAI 176_ NVLEM 181_ IKTEF 186_ TLTEA 191_ VVESS 196_ RKLVK 201_ EAAVI 206_ ICIKN 211_ KEFEK 216_ ASKIL 221_ KKHMS 226_ KDPTT 231_ QKLRN 236_ DLLNI 241_ IREKN 246_ LAHPV 251_ IQNFS 256_ YETFQ 261_ QKMLR 266_ FLESH 271_ LDDAE 276_ PYLLT 281_ MAKKA 286_ LKSES 291_ AASST 296_ GKEDK 301_ QPAPG 306_ PVEKP 311_ PREPA 316_ RQLRN 321_ PPTTI 326_ GMMTL 331_ KAAFK 336_ TLSGA 341_ QDSEA 346_ AFAKL 351_ DQKDL 356_ VLPTQ 361_ ALPAS 366_ PALKN 371_ KRPRK 376_ DENES 381_ SAPAD 386_ GEGGS 391_ ELQPK 396_ NKRMT 401_ ISRLV 406_ LEEDS 411_ QSTEP 416_ SAGLN 421_ SSQEA 426_ ASAPP 431_ SKPTV 436_ LNQPL 441_ PGEKN 446_ PKVPK 451_ GKWNS 456_ SNGVE 461_ EKETW 466_ VEEDE 471_ LFQVQ 476_ AAPDE 481_ DSTTN 486_ ITKKQ 491_ KWTVE 496_ ESEWV 501_ KAGVQ 506_ KYGEG 511_ NWAAI 516_ SKNYP 521_ FVNRT 526_ AVMIK 531_ DRWRT 536_MKRLG
1: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity)