Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)
1_MPGPT 6_ QTLSP 11_ NGENN 16_ NDIIQ 21_ DNNGT 26_ IIPFR 31_ KHTVR 36_ GERSY 41_ SWGMA 46_ VNVYS 51_ TSITQ 56_ ETMSR 61_ HDIIA 66_ WVNDI 71_ VSLNY 76_ TKVEQ 81_ LCSGA 86_ AYCQF 91_ MDMLF 96_ PGCIS 101_ LKKVK 106_ FQAKL 111_ EHEYI 116_ HNFKL 121_ LQASF 126_ KRMNV 131_ DKVIP 136_ VEKLV 141_ KGRFQ 146_ DNLDF 151_ IQWFK 156_ KFYDA 161_ NYDGK 166_ EYDPV 171_ EARQG 176_ QDAIP 181_ PPDPG 186_ EQIFN 191_ LPKKS 196_ HHANS 201_ PTAGA 206_ AKSSP 211_ AAKPG 216_ STPSR 221_ PSSAK 226_ RASSS 231_ GSASK 236_ SDKDL 241_ ETQVI 246_ QLNEQ 251_ VHSLK 256_ LALEG 261_ VEKER 266_ DFYFG 271_ KLREI 276_ ELLCQ 281_ EHGQE 286_ NDDLV 291_ QRLMD 296_ ILYAS 301_ EEHEG 306_ HTEEP 311_ EAEEQ 316_ AHEQQ 321_PPQQE
1: Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684)