Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
1_MEGTA 6_ GTITS 11_ NEWSS 16_ PTSPE 21_ GSTAS 26_ GGSQA 31_ LDKPI 36_ DNDAE 41_ GVWSP 46_ DIEQS 51_ FQEAL 56_ AIYPP 61_ CGRRK 66_ IILSD 71_ EGKMY 76_ GRNEL 81_ IARYI 86_ KLRTG 91_ KTRTR 96_ KQVSS 101_ HIQVL 106_ ARRKA 111_ REIQA 116_ KLKDQ 121_ AAKDK 126_ ALQSM 131_ AAMSS 136_ AQIIS 141_ ATAFH 146_ SSMAL 151_ ARGPG 156_ RPAVS 161_ GFWQG 166_ ALPGQ 171_ AGTSH 176_ DVKPF 181_ SQQTY 186_ AVQPP 191_ LPLPG 196_ FESPA 201_ GPAPS 206_ PSAPP 211_ APPWQ 216_ GRSVA 221_ SSKLW 226_ MLEFS 231_ AFLEQ 236_ QQDPD 241_ TYNKH 246_ LFVHI 251_ GQSSP 256_ SYSDP 261_ YLEAV 266_ DIRQI 271_ YDKFP 276_ EKKGG 281_ LKDLF 286_ ERGPS 291_ NAFFL 296_ VKFWA 301_ DLNTN 306_ IEDEG 311_ SSFYG 316_ VSSQY 321_ ESPEN 326_ MIITC 331_ STKVC 336_ SFGKQ 341_ VVEKV 346_ ETEYA 351_ RYENG 356_ HYSYR 361_ IHRSP 366_ LCEYM 371_ INFIH 376_ KLKHL 381_ PEKYM 386_ MNSVL 391_ ENFTI 396_ LQVVT 401_ NRDTQ 406_ ETLLC 411_ IAYVF 416_ EVSAS 421_ EHGAQ 426_HHIYR
1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif