Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)
1_MGEPR 6_ AGAAL 11_ DDGSG 16_ WTGSE 21_ EGSEE 26_ GTGGS 31_ EGAGG 36_ DGGPD 41_ AEGVW 46_ SPDIE 51_ QSFQE 56_ ALAIY 61_ PPCGR 66_ RKIIL 71_ SDEGK 76_ MYGRN 81_ ELIAR 86_ YIKLR 91_ TGKTR 96_ TRKQV 101_ SSHIQ 106_ VLARR 111_ KSREI 116_ QSKLK 121_ DQVSK 126_ DKAFQ 131_ TMATM 136_ SSAQL 141_ ISAPS 146_ LQAKL 151_ GPTGP 156_ QASEL 161_ FQFWS 166_ GGSGP 171_ PWNVP 176_ DVKPF 181_ SQTPF 186_ TLSLT 191_ PPSTD 196_ LPGYE 201_ PPQAL 206_ SPLPP 211_ PTPSP 216_ PAWQA 221_ RGLGT 226_ ARLQL 231_ VEFSA 236_ FVEPP 241_ DAVDS 246_ YQRHL 251_ FVHIS 256_ QHCPS 261_ PGAPP 266_ LESVD 271_ VRQIY 276_ DKFPE 281_ KKGGL 286_ RELYD 291_ RGPPH 296_ AFFLV 301_ KFWAD 306_ LNWGP 311_ SGEEA 316_ GAGGS 321_ ISSGG 326_ FYGVS 331_ SQYES 336_ LEHMT 341_ LTCSS 346_ KVCSF 351_ GKQVV 356_ EKVET 361_ ERAQL 366_ EDGRF 371_ VYRLL 376_ RSPMC 381_ EYLVN 386_ FLHKL 391_ RQLPE 396_ RYMMN 401_ SVLEN 406_ FTILQ 411_ VVTNR 416_ DTQEL 421_ LLCTA 426_ YVFEV 431_ STSER 436_ GAQHH 441_IYRLV
1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif