Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1)
1_MAGER 6_ PPLRG 11_ PGPGP 16_ GEVPG 21_ EGPPG 26_ PGGTG 31_ GGPGR 36_ GRPSS 41_ YRALR 46_ SAVSS 51_ LARVD 56_ DFHCA 61_ EKIGA 66_ GFFSE 71_ VYKVR 76_ HRQSG 81_ QVMVL 86_ KMNKL 91_ PSNRG 96_ NTLRE 101_ VQLMN 106_ RLRHP 111_ NILRF 116_ MGVCV 121_ HQGQL 126_ HALTE 131_ YMNGG 136_ TLEQL 141_ LSSPE 146_ PLSWP 151_ VRLHL 156_ ALDIA 161_ RGLRY 166_ LHSKG 171_ VFHRD 176_ LTSKN 181_ CLVRR 186_ EDRGF 191_ TAVVG 196_ DFGLA 201_ EKIPV 206_ YREGA 211_ RKEPL 216_ AVVGS 221_ PYWMA 226_ PEVLR 231_ GELYD 236_ EKADV 241_ FAFGI 246_ VLCEL 251_ IARVP 256_ ADPDY 261_ LPRTE 266_ DFGLD 271_ VPAFR 276_ TLVGD 281_ DCPLP 286_ FLLLA 291_ IHCCN 296_ LEPST 301_ RAPFT 306_ EITQH 311_ LEWIL 316_ EQLPE 321_ PAPLT 326_ RTALT 331_ HNQGS 336_ VARGG 341_ PSATL 346_ PRPDP 351_ RLSRS 356_ RSDLF 361_ LPPSP 366_ ESPPN 371_ WGDNL 376_ TRVNP 381_ FSLRE 386_ DLRGG 391_ KIKLL 396_ DTPSK 401_ PVLPL 406_ VPPSP 411_ FPSTQ 416_ LPLVT 421_ TPETL 426_ VQPGT 431_ PARRC 436_ RSLPS 441_ SPELP 446_ RRMET 451_ ALPGP 456_ GPPAV 461_ GPSAE 466_ EKMEC 471_ EGSSP 476_ EPEPP 481_ GPAPQ 486_ LPLAV 491_ ATDNF 496_ ISTCS 501_ SASQP 506_ WSPRS 511_ GPVLN 516_ NNPPA 521_ VVVNS 526_ PQGWA 531_ GEPWN 536_ RAQHS 541_ LPRAA 546_ ALERT 551_ EPSPP 556_ PSAPR 561_ EPDEG 566_ LPCPG 571_ CCLGP 576_ FSFGF 581_ LSMCP 586_ RPTPA 591_ VARYR 596_ NLNCE 601_ AGSLL 606_ CHRGH 611_ HAKPP 616_ TPSLQ 621_LPGAR
1: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)