Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)
1_MVLAQ 6_ SRVSA 11_ GVGSP 16_ HCSGS 21_ GGGGS 26_ DSFPW 31_ PASHP 36_ GNPQC 41_ SFSTA 46_ FLASP 51_ RLSRG 56_ TLAYL 61_ PPAPW 66_ SSLAT 71_ PSALL 76_ GSSCA 81_ PPPPP 86_ ARCPQ 91_ PRALS 96_ PELGT 101_ KAGPR 106_ RPHRW 111_ ELPRS 116_ PSQGA 121_ QGPAP 126_ RRRLL 131_ ETMKG 136_ IVAAS 141_ GSETE 146_ DEDSM 151_ DIPLD 156_ LSSSA 161_ GSGKR 166_ RRRGN 171_ LPKES 176_ VQILR 181_ DWLYE 186_ HRYNA 191_ YPSEQ 196_ EKALL 201_ SQQTH 206_ LSTLQ 211_ VCNWF 216_ INARR 221_ RLLPD 226_ MLRKD 231_ GKDPN 236_ QFTIS 241_ RRGAK 246_ ISETS 251_ SVESV 256_ MGIKN 261_ FMPAL 266_ EETPF 271_ HSCTA 276_ GPNPT 281_ LGRPL 286_ SPKPS 291_ SPGSV 296_ LARPS 301_ VICHT 306_ TVTAL 311_ KDVPF 316_ SLCQS 321_ VGVGQ 326_ NTDIQ 331_ QIAAK 336_ NFTDT 341_ SLMYP 346_ EDTCK 351_ SGPST 356_ NTQSG 361_ LFNTP 366_ PPTPP 371_ DLNQD 376_ FSGFQ 381_ LLVDV 386_ ALKRA 391_ AEMEL 396_QAKLT
1: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities