Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
1_MAAGQ 6_ NGHEE 11_ WVGSA 16_ YLFVE 21_ SSLDK 26_ VVLSD 31_ AYAHP 36_ QQKVA 41_ VYRAL 46_ QAALA 51_ ESGGS 56_ PDVLQ 61_ MLKIH 66_ RSDPQ 71_ LIVQL 76_ RFCGR 81_ QPCGR 86_ FLRAY 91_ REGAL 96_ RAALQ 101_ RSLAA 106_ ALAQH 111_ SVPLQ 116_ LELRA 121_ GAERL 126_ DALLA 131_ DEERC 136_ LSCIL 141_ AQQPD 146_ RLRDE 151_ ELAEL 156_ EDALR 161_ NLKCG 166_ SGARG 171_ GDGEV 176_ ASAPL 181_ QPPVP 186_ SLSEV 191_ KPPPP 196_ PPPAQ 201_ TFLFQ 206_ GQPVV 211_ NRPLS 216_ LKDQQ 221_ TFARS 226_ VGLKW 231_ RKVGR 236_ SLQRG 241_ CRALR 246_ DPALD 251_ SLAYE 256_ YEREG 261_ LYEQA 266_ FQLLR 271_ RFVQA 276_ EGRRA 281_ TLQRL 286_ VEALE 291_ ENELT 296_ SLAED 301_ LLGLT 306_DPNGG
1: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:23955153, PubMed:7758105, PubMed:8612133). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity)