Translocating chain-associated membrane protein 1 (Protein TRAM1)
1_MAIRK 6_ KSTKS 11_ PPVLS 16_ HEFVL 21_ QNHAD 26_ IVSCV 31_ AMVFL 36_ LGLMF 41_ EITAK 46_ ASIIF 51_ VTLQY 56_ NVTLP 61_ ATEEQ 66_ ATESV 71_ SLYYY 76_ GIKDL 81_ ATVFF 86_ YMLVA 91_ IIIHA 96_ VIQEY 101_ MLDKI 106_ NRRMH 111_ FSKTK 116_ HSKFN 121_ ESGQL 126_ SAFYL 131_ FACVW 136_ GTFIL 141_ ISENY 146_ ISDPT 151_ ILWRA 156_ YPHNL 161_ MTFQM 166_ KFFYI 171_ SQLAY 176_ WLHAF 181_ PELYF 186_ QKTKK 191_ EDIPR 196_ QLVYI 201_ GLYLF 206_ HIAGA 211_ YLLNL 216_ NHLGL 221_ VLLVL 226_ HYFVE 231_ FLFHI 236_ SRLFY 241_ FSNEK 246_ YQKGF 251_ SLWAV 256_ LFVLG 261_ RLLTL 266_ ILSVL 271_ TVGFG 276_ LARAE 281_ NQKLD 286_ FSTGN 291_ FNVLA 296_ VRIAV 301_ LASIC 306_ VTQAF 311_ MMWKF 316_ INFQL 321_ RRWRE 326_ HSAFQ 331_ APAVK 336_ KKPTV 341_ TKGRS 346_ SKKGT 351_ ENGVN 356_ GTLTS 361_ NVADS 366_PRNKK
1: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:12475939, PubMed:1315422, PubMed:32013668, PubMed:8616892, PubMed:9506517). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023)
2: (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells