Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)
1_MDEAV 6_ GDLKQ 11_ ALPCV 16_ AESPT 21_ VHVEV 26_ HQRGS 31_ STAKK 36_ EDINL 41_ SVRKL 46_ LNRHN 51_ IVFGD 56_ YTWTE 61_ FDEPF 66_ LTRNV 71_ QSVSI 76_ IDTEL 81_ KVKDS 86_ QPIDL 91_ SACTV 96_ ALHIF 101_ QLNED 106_ GPSSE 111_ NLEEE 116_ TENII 121_ AANHW 126_ VLPAA 131_ EFHGL 136_ WDSLV 141_ YDVEV 146_ KSHLL 151_ DYVMT 156_ TLLFS 161_ DKNVN 166_ SNLIT 171_ WNRVV 176_ LLHGP 181_ PGTGK 186_ TSLCK 191_ ALAQK 196_ LTIRL 201_ SSRYR 206_ YGQLI 211_ EINSH 216_ SLFSK 221_ WFSES 226_ GKLVT 231_ KMFQK 236_ IQDLI 241_ DDKDA 246_ LVFVL 251_ IDEVE 256_ SLTAA 261_ RNACR 266_ AGTEP 271_ SDAIR 276_ VVNAV 281_ LTQID 286_ QIKRH 291_ SNVVI 296_ LTTSN 301_ ITEKI 306_ DVAFV 311_ DRADI 316_ KQYIG 321_ PPSAA 326_ AIFKI 331_ YLSCL 336_ EELMK 341_ CQIIY 346_ PRQQL 351_ LTLRE 356_ LEMIG 361_ FIENN 366_ VSKLS 371_ LLLND 376_ ISRKS 381_ EGLSG 386_ RVLRK 391_ LPFLA 396_ HALYV 401_ QAPTV 406_ TIEGF 411_ LQALS 416_ LAVDK 421_ QFEER 426_KKLAA
1: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959)