Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
1_MKAQG 6_ ETEES 11_ EKLSK 16_ MSSLL 21_ ERLHA 26_ KFNQN 31_ RPWSE 36_ TIKLV 41_ RQVME 46_ KRVVM 51_ SSGGH 56_ QHLVS 61_ CLETL 66_ QKALK 71_ VTSLP 76_ AMTDR 81_ LESIA 86_ RQNGL 91_ GSHLS 96_ ASGTE 101_ CYITS 106_ DMFYV 111_ EVQLD 116_ PAGQL 121_ CDVKV 126_ AHHGE 131_ NPVSC 136_ PELVQ 141_ QLREK 146_ NFDEF 151_ SKHLK 156_ GLVNL 161_ YNLPG 166_ DNKLK 171_ TKMYL 176_ ALQSL 181_ EQDLS 186_ KMAIM 191_ YWKAT 196_ NAGPL 201_ DKILH 206_ GSVGY 211_ LTPRS 216_ GGHLM 221_ NLKYY 226_ VSPSD 231_ LLDDK 236_ TASPI 241_ ILHEN 246_ NVSRS 251_ LGMNA 256_ SVTIE 261_ GTSAV 266_ YKLPI 271_ APLIM 276_ GSHPV 281_ DNKWT 286_ PSFSS 291_ ITSAN 296_ SVDLP 301_ ACFFL 306_ KFPQP 311_ IPVSR 316_ AFVQK 321_ LQNCT 326_ GIPLF 331_ ETQPT 336_ YAPLY 341_ ELITQ 346_ FELSK 351_ DPDPI 356_ PLNHN 361_ MRFYA 366_ ALPGQ 371_ QHCYF 376_ LNKDA 381_ PLPDG 386_ RSLQG 391_ TLVSK 396_ ITFQH 401_ PGRVP 406_ LILNL 411_ IRHQV 416_ AYNTL 421_ IGSCV 426_ KRTIL 431_ KEDSP 436_ GLLQF 441_ EVCPL 446_ SESRF 451_ SVSFQ 456_ HPVND 461_ SLVCV 466_ VMDVQ 471_ DSTHV 476_ SCKLY 481_ KGLSD 486_ ALICT 491_ DDFIA 496_ KVVQR 501_ CMSIP 506_ VTMRA 511_ IRRKA 516_ ETIQA 521_ DTPAL 526_ SLIAE 531_ TVEDM 536_ VKKNL 541_ PPASS 546_ PGYGM 551_ TTGNN 556_ PMSGT 561_ TTPTN 566_ TFPGG 571_ PITTL 576_ FNMSM 581_ SIKDR 586_ HESVG 591_ HGEDF 596_ SKVSQ 601_ NPILT 606_ SLLQI 611_ TGNGG 616_ STIGS 621_ SPTPP 626_ HHTPP 631_ PVSSM 636_ AGNTK 641_ NHPML 646_ MNLLK 651_ DNPAQ 656_ DFSTL 661_ YGSSP 666_ LERQN 671_ SSSGS 676_ PRMEI 681_ CSGSN 686_ KTKKK 691_ KSSRL 696_ PPEKP 701_ KHQTE 706_ DDFQR 711_ ELFSM 716_ DVDSQ 721_ NPIFD 726_ VNMTA 731_ DTLDT 736_ PHITP 741_ APSQC 746_ STPPT 751_ TYPQP 756_ VPHPQ 761_ PSIQR 766_ MVRLS 771_ SSDSI 776_ GPDVT 781_ DILSD 786_ IAEEA 791_ SKLPS 796_ TSDDC 801_ PAIGT 806_ PLRDS 811_ SSSGH 816_ SQSTL 821_ FDSDV 826_ FQTNN 831_ NENPY 836_ TDPAD 841_ LIADA 846_ AGSPS 851_ SDSPT 856_ NHFFH 861_ DGVDF 866_ NPDLL 871_ NSQSQ 876_ SGFGE 881_ EYFDE 886_ SSQSG 891_ DNDDF 896_ KGFAS 901_ QALNT 906_ LGVPM 911_ LGGDN 916_ GETKF 921_ KGNNQ 926_ ADTVD 931_ FSIIS 936_ VAGKA 941_ LAPAD 946_ LMEHH 951_ SGSQG 956_ PLLTT 961_ GDLGK 966_ EKTQK 971_ RVKEG 976_ NGTSN 981_ STLSG 986_ PGLDS 991_ KPGKR 996_ SRTPS 1001_ NDGKS 1006_ KDKPP 1011_ KRKKA 1016_ DTEGK 1021_ SPSHS 1026_ SSNRP 1031_ FTPPT 1036_ STGGS 1041_ KSPGS 1046_ AGRSQ 1051_ TPPGV 1056_ ATPPI 1061_ PKITI 1066_ QIPKG 1071_ TVMVG 1076_ KPSSH 1081_ SQYTS 1086_ SGSVS 1091_ SSGSK 1096_ SHHSH 1101_ SSSSS 1106_ SSAST 1111_ SGKMK 1116_ SSKSE 1121_ GSSSS 1126_ KLSSS 1131_ MYSSQ 1136_ GSSGS 1141_ SQSKN 1146_ SSQSG 1151_ GKPGS 1156_ SPITK 1161_ HGLSS 1166_ GSSST 1171_ KMKPQ 1176_ GKPSS 1181_ LMNPS 1186_ LSKPN 1191_ ISPSH 1196_ SRPPG 1201_ GSDKL 1206_ ASPMK 1211_ PVPGT 1216_ PPSSK 1221_ AKSPI 1226_ SSGSG 1231_ GSHMS 1236_ GTSSS 1241_ SGMKS 1246_ SSGLG 1251_ SSGSL 1256_ SQKTP 1261_ PSSNS 1266_ CTASS 1271_ SSFSS 1276_ SGSSM 1281_ SSSQN 1286_ QHGSS 1291_ KGKSP 1296_ SRNKK 1301_ PSLTA 1306_ VIDKL 1311_ KHGVV 1316_ TSGPG 1321_ GEDPL 1326_ DGQMG 1331_ VSTNS 1336_ SSHPM 1341_ SSKHN 1346_ MSGGE 1351_ FQGKR 1356_ EKSDK 1361_ DKSKV 1366_ STSGS 1371_ SVDSS 1376_ KKTSE 1381_ SKNVG 1386_ STGVA 1391_ KIIIS 1396_ KHDGG 1401_ SPSIK 1406_ AKVTL 1411_ QKPGE 1416_ SSGEG 1421_ LRPQM 1426_ ASSKN 1431_ YGSPL 1436_ ISGST 1441_ PKHER 1446_ GSPSH 1451_ SKSPA 1456_ YTPQN 1461_ LDSES 1466_ ESGSS 1471_ IAEKS 1476_ YQNSP 1481_ SSDDG 1486_ IRPLP 1491_ EYSTE 1496_ KHKKH 1501_ KKEKK 1506_ KVKDK 1511_ DRDRD 1516_ RDKDR 1521_ DKKKS 1526_ HSIKP 1531_ ESWSK 1536_ SPISS 1541_ DQSLS 1546_ MTSNT 1551_ ILSAD 1556_ RPSRL 1561_ SPDFM 1566_ IGEED 1571_ DDLMD 1576_VALIG
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)