Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)
1_MAVAG 6_ AVSGE 11_ PLVHW 16_ CTQQL 21_ RKTFG 26_ LDVSE 31_ EIIQY 36_ VLSIE 41_ SAEEI 46_ REYVT 51_ DLLQG 56_ NEGKK 61_ GQFIE 66_ ELITK 71_ WQKND 76_ QELIS 81_ DPLQQ 86_ CFKKD 91_ EILDG 96_ QKSGD 101_ HLKRG 106_ RKKGR 111_ NRQEV 116_ PAFTE 121_ PDTTA 126_ EVKTP 131_ FDLAK 136_ AQENS 141_ NSVKK 146_ KTKFV 151_ NLYTR 156_ EGQDR 161_ LAVLL 166_ PGRHP 171_ CDCLG 176_ QKHKL 181_ INNCL 186_ ICGRI 191_ VCEQE 196_ GSGPC 201_ LFCGT 206_ LVCTH 211_ EEQDI 216_ LQRDS 221_ NKSQK 226_ LLKKL 231_ MSGVE 236_ NSGKV 241_ DISTK 246_ DLLPH 251_ QELRI 256_ KSGLE 261_ KAIKH 266_ KDKLL 271_ EFDRT 276_ SIRRT 281_ QVIDD 286_ ESDYF 291_ ASDSN 296_ QWLSK 301_ LERET 306_ LQKRE 311_ EELRE 316_ LRHAS 321_ RLSKK 326_ VTIDF 331_ AGRKI 336_ LEEEN 341_ SLAEY 346_ HSRLD 351_ ETIQA 356_ IANGT 361_ LNQPL 366_ TKLDR 371_ SSEEP 376_ LGVLV 381_ NPNMY 386_ QSPPQ 391_ WVDHT 396_ GAASQ 401_ KKAFR 406_ SSGFG 411_ LEFNS 416_ FQHQL 421_ RIQDQ 426_ EFQEG 431_ FDGGW 436_ CLSVH 441_ QPWAS 446_ LLVRG 451_ IKRVE 456_ GRSWY 461_ TPHRG 466_ RLWIA 471_ ATAKK 476_ PSPQE 481_ VSELQ 486_ ATYRL 491_ LRGKD 496_ VEFPN 501_ DYPSG 506_ CLLGC 511_ VDLID 516_ CLSQK 521_ QFKEQ 526_ FPDIS 531_ QESDS 536_ PFVFI 541_ CKNPQ 546_ EMVVK 551_ FPIKG 556_ NPKIW 561_ KLDSK 566_ IHQGA 571_ KKGLM 576_KQNKA
1: Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773)