High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7)
1_MPKRK 6_ SPENT 11_ EGKDG 16_ SKVTK 21_ QEPTR 26_ RSARL 31_ SAKPA 36_ PPKPE 41_ PKPRK 46_ TSAKK 51_ EPGAK 56_ ISRGA 61_ KGKKE 66_ EKQEA 71_ GKEGT 76_ APSEN 81_ GETKA 86_ EEAQK 91_TESVD
1: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity)