Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
1_MLSSI 6_ KCVLV 11_ GDSAV 16_ GKTSL 21_ LVRFT 26_ SETFP 31_ EAYKP 36_ TVYEN 41_ TGVDV 46_ FMDGI 51_ QISLG 56_ LWDTA 61_ GNDAF 66_ RSIRP 71_ LSYQQ 76_ ADVVL 81_ MCYSV 86_ ANHNS 91_ FLNLK 96_ NKWIG 101_ EIRSN 106_ LPCTP 111_ VLVVA 116_ TQTDQ 121_ REMGP 126_ HRASC 131_ VNAME 136_ GKKLA 141_ QDVRA 146_ KGYLE 151_ CSALS 156_ NRGVQ 161_ QVFEC 166_ AVRTA 171_ VNQAR 176_ RRNRR 181_ RLFSI 186_NECKI
1: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils