Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)
1_MMQDV 6_ SSSPV 11_ SPADD 16_ SLSNS 21_ EEEPD 26_ RQQPP 31_ SGKRG 36_ GRKRR 41_ SSRRS 46_ AGGGA 51_ GPGGA 56_ AGGGV 61_ GGGDE 66_ PGSPA 71_ QGKRG 76_ KKSAG 81_ CGGGG 86_ GAGGG 91_ GGSSS 96_ GGGSP 101_ QSYEE 106_ LQTQR 111_ VMANV 116_ RERQR 121_ TQSLN 126_ EAFAA 131_ LRKII 136_ PTLPS 141_ DKLSK 146_ IQTLK 151_ LAARY 156_ IDFLY 161_ QVLQS 166_ DELDS 171_ KMASC 176_ SYVAH 181_ ERLSY 186_ AFSVW 191_ RMEGA 196_WSMSA
1: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity)