Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
1_MAVNV 6_ YSTSV 11_ TSDNL 16_ SRHDM 21_ LAWIN 26_ ESLQL 31_ NLTKI 36_ EQLCS 41_ GAAYC 46_ QFMDM 51_ LFPGS 56_ IALKK 61_ VKFQA 66_ KLEHE 71_ YIQNF 76_ KILQA 81_ GFKRM 86_ GVDKI 91_ IPVDK 96_ LVKGK 101_ FQDNF 106_ EFVQW 111_ FKKFF 116_ DANYD 121_ GKDYD 126_ PVAAR 131_ QGQET 136_ AVAPS 141_ LVAPA 146_ LNKPK 151_ KPLTS 156_ SSAAP 161_ QRPIS 166_ TQRTA 171_ AAPKA 176_ GPGVV 181_ RKNPG 186_ VGNGD 191_ DEAAE 196_ LMQQV 201_ NVLKL 206_ TVEDL 211_ EKERD 216_ FYFGK 221_ LRNIE 226_ LICQE 231_ NEGEN 236_ DPVLQ 241_ RIVDI 246_ LYATD 251_ EGFVI 256_ PDEGG 261_PQEEQ
1: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity)