U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)
1_MAAPE 6_ KMTFP 11_ EKPSH 16_ KKYRA 21_ ALKKE 26_ KRKKR 31_ RQELA 36_ RLRDS 41_ GLSQK 46_ EEEED 51_ TFIEE 56_ QQLEE 61_ EKLLE 66_ RERQR 71_ LHEEW 76_ LLREQ 81_ KAQEE 86_ FRIKK 91_ EKEEA 96_ AKKRQ 101_ EEQER 106_ KLKEQ 111_ WEEQQ 116_ RKERE 121_ EEEQK 126_ RQEKK 131_ EKEEA 136_ LQKML 141_ DQAEN 146_ ELENG 151_ TTWQN 156_ PEPPV 161_ DFRVM 166_ EKDRA 171_ NCPFY 176_ SKTGA 181_ CRFGD 186_ RCSRK 191_ HNFPT 196_ SSPTL 201_ LIKSM 206_ FTTFG 211_ MEQCR 216_ RDDYD 221_ PDASL 226_ EYSEE 231_ ETYQQ 236_ FLDFY 241_ EDVLP 246_ EFKNV 251_ GKVIQ 256_ FKVSC 261_ NLEPH 266_ LRGNV 271_ YVQYQ 276_ SEEEC 281_ QAALS 286_ LFNGR 291_ WYAGR 296_ QLQCE 301_ FCPVT 306_ RWKMA 311_ ICGLF 316_ EIQQC 321_ PRGKH 326_ CNFLH 331_ VFRNP 336_ NNEFW 341_ EANRD 346_ IYLSP 351_ DRTGS 356_ SFGKN 361_ SERRE 366_ RMGHH 371_ DDYYS 376_ RLRGR 381_ RNPSP 386_ DHSYK 391_ RNGES 396_ ERKSS 401_ RHRGK 406_ KSHKR 411_ TSKSR 416_ ERHNS 421_ RSRGR 426_ NRDRS 431_ RDRSR 436_ GRGSR 441_ SRSRS 446_ RSRRS 451_ RRSRS 456_ QSSSR 461_ SRSRG 466_ RRRSG 471_ NRDRT 476_VQSPK
1: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing