ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1)
1_MEFLS 6_ EKFAL 11_ KSPPS 16_ KNSDF 21_ YMGAG 26_ GPLEH 31_ VMETL 36_ DNESF 41_ YSKAS 46_ AGKCV 51_ QAFGP 56_ LPRAE 61_ HHVRL 66_ ERTSP 71_ CQDSS 76_ VNYGI 81_ TKVEG 86_ QPLHT 91_ ELNRA 96_ MDNCN 101_ SLRMS 106_ PVKGM 111_ QEKGE 116_ LDELG 121_ DKCDS 126_ NVSSS 131_ KKRRH 136_ RTTFT 141_ SLQLE 146_ ELEKV 151_ FQKTH 156_ YPDVY 161_ VREQL 166_ ALRTE 171_ LTEAR 176_ VQVWF 181_ QNRRA 186_ KWRKR 191_ ERYGQ 196_ IQQAK 201_ SHFAA 206_ TYDIS 211_ VLPRT 216_ DSYPQ 221_ IQNNL 226_ WAGNA 231_ SGGSV 236_ VTSCM 241_ LPRDT 246_ SSCMT 251_ PYSHS 256_ PRTDS 261_ SYTGF 266_ SNHQN 271_ QFSHV 276_ PLNNF 281_ FTDSL 286_ LTGAT 291_ NGHAF 296_ ETKPE 301_ FERRS 306_ SSIAV 311_ LRMKA 316_ KEHTA 321_NISWA
1: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509)