Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)
1_MFFAC 6_ YCALR 11_ TNVKK 16_ YRYQD 21_ EDAPH 26_ DHSLP 31_ RLTHE 36_ VRGPE 41_ LVHVS 46_ EKNLS 51_ QIENV 56_ HGYVL 61_ QSHIS 66_ PLKAS 71_ PAPII 76_ VNTDT 81_ LDTIP 86_ YVNGT 91_ EIEYE 96_ FEEIT 101_ LERGN 106_ SGLGF 111_ SIAGG 116_ TDNPH 121_ IGDDP 126_ GIFIT 131_ KIIPG 136_ GAAAE 141_ DGRLR 146_ VNDCI 151_ LRVNE 156_ VDVSE 161_ VSHSK 166_ AVEAL 171_ KEAGS 176_ IVRLY 181_ VRRRR 186_ PILET 191_ VVEIK 196_ LFKGP 201_ KGLGF 206_ SIAGG 211_ VGNQH 216_ IPGDN 221_ SIYVT 226_ KIIDG 231_ GAAQK 236_ DGRLQ 241_ VGDRL 246_ LMVNN 251_ YSLEE 256_ VTHEE 261_ AVAIL 266_ KNTSE 271_ VVYLK 276_ VGKPT 281_ TIYMT 286_ DPYGP 291_ PDITH 296_ SYSPP 301_ MENHL 306_ LSGNN 311_ GTLEY 316_ KTSLP 321_ PISPG 326_ RYSPI 331_ PKHML 336_ VDDDY 341_ TRPPE 346_ PVYST 351_ VNKLC 356_ DKPAS 361_ PRHYS 366_ PVECD 371_ KSFLL 376_ SAPYS 381_ HYHLG 386_ LLPDS 391_ EMTSH 396_ SQHST 401_ ATRQP 406_ SMTLQ 411_ RAVSL 416_ EGEPR 421_ KVVLH 426_ KGSTG 431_ LGFNI 436_ VGGED 441_ GEGIF 446_ VSFIL 451_ AGGPA 456_ DLSGE 461_ LQRGD 466_ QILSV 471_ NGIDL 476_ RGASH 481_ EQAAA 486_ ALKGA 491_ GQTVT 496_ IIAQY 501_ QPEDY 506_ ARFEA 511_ KIHDL 516_ REQMM 521_ NHSMS 526_ SGSGS 531_ LRTNQ 536_ KRSLY 541_ VRAMF 546_ DYDKS 551_ KDSGL 556_ PSQGL 561_ SFKYG 566_ DILHV 571_ INASD 576_ DEWWQ 581_ ARRVM 586_ LEGDS 591_ EEMGV 596_ IPSKR 601_ RVERK 606_ ERARL 611_ KTVKF 616_ NAKPG 621_ VIDSK 626_ GSFND 631_ KRKKS 636_ FIFSR 641_ KFPFY 646_ KNKEQ 651_ SEQET 656_ SDPER 661_ GQEDL 666_ ILSYE 671_ PVTRQ 676_ EINYT 681_ RPVII 686_ LGPMK 691_ DRIND 696_ DLISE 701_ FPDKF 706_ GSCVP 711_ HTTRP 716_ KRDYE 721_ VDGRD 726_ YHFVI 731_ SREQM 736_ EKDIQ 741_ EHKFI 746_ EAGQY 751_ NDNLY 756_ GTSVQ 761_ SVRFV 766_ AERGK 771_ HCILD 776_ VSGNA 781_ IKRLQ 786_ VAQLY 791_ PIAIF 796_ IKPRS 801_ LEPLM 806_ EMNKR 811_ LTEEQ 816_ AKKTY 821_ DRAIK 826_ LEQEF 831_ GEYFT 836_ AIVQG 841_ DTLED 846_ IYNQC 851_ KLVIE 856_ EQSGP 861_FIWIP
1: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity)