TSC22 domain family protein 1 (Cerebral protein 2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)
1_MHQPP 6_ ESTAA 11_ AAAAA 16_ DISAR 21_ KMAHP 26_ AMFPR 31_ RGSGS 36_ GSASA 41_ LNAAG 46_ TGVGS 51_ NATSS 56_ EDFPP 61_ PSLLQ 66_ PPPPA 71_ ASSTS 76_ GPQPP 81_ PPQSL 86_ NLLSQ 91_ AQLQA 96_ QPLAP 101_ GGTQM 106_ KKKSG 111_ FQITS 116_ VTPAQ 121_ ISASI 126_ SSNNS 131_ IAEDT 136_ ESYDD 141_ LDESH 146_ TEDLS 151_ SSEIL 156_ DVSLS 161_ RATDL 166_ GEPER 171_ SSSEE 176_ TLNNF 181_ QEAET 186_ PGAVS 191_ PNQPH 196_ LPQPH 201_ LPHLP 206_ QQNVV 211_ INGNA 216_ HPHHL 221_ HHHHQ 226_ IHHGH 231_ HLQHG 236_ HHHPS 241_ HVAVA 246_ SASIT 251_ GGPPS 256_ SPVSR 261_ KLSTT 266_ GSSDS 271_ ITPVA 276_ PTSAV 281_ SSSGS 286_ PASVM 291_ TNMRA 296_ PSTTG 301_ GIGIN 306_ SVTGT 311_ STVNN 316_ VNITA 321_ VGSFN 326_ PNVTS 331_ SMLGN 336_ VNIST 341_ SNIPS 346_ AAGVS 351_ VGPGV 356_ TSGVN 361_ VNILS 366_ GMGNG 371_ TISSS 376_ AAVSS 381_ VPNAA 386_ AGMTG 391_ GSVSS 396_ QQQQP 401_ TVNTS 406_ RFRVV 411_ KLDSS 416_ SEPFK 421_ KGRWT 426_ CTEFY 431_ EKENA 436_ VPATE 441_ GVLIN 446_ KVVET 451_ VKQNP 456_ IEVTS 461_ EREST 466_ SGSSV 471_ SSSVS 476_ TLSHY 481_ TESVG 486_ SGEMG 491_ APTVV 496_ VQQQQ 501_ QQQQQ 506_ QQQQP 511_ ALQGV 516_ TLQQM 521_ DFGST 526_ GPQSI 531_ PAVSI 536_ PQSIS 541_ QSQIS 546_ QVQLQ 551_ SQELS 556_ YQQKQ 561_ GLQPV 566_ PLQAT 571_ MSAAT 576_ GIQPS 581_ PVNVV 586_ GVTSA 591_ LGQQP 596_ SISSL 601_ AQPQL 606_ PYSQA 611_ APPVQ 616_ TPLPG 621_ APPPQ 626_ QLQYG 631_ QQQPM 636_ VSTQM 641_ APGHV 646_ KSVTQ 651_ NPASE 656_ YVQQQ 661_ PILQT 666_ AMSSG 671_ QPSSA 676_ GVGAG 681_ TTVIP 686_ VAQPQ 691_ GIQLP 696_ VQPTA 701_ VPAQP 706_ AGASV 711_ QPVGQ 716_ APAAV 721_ SAVPT 726_ GSQIA 731_ NIGQQ 736_ ANIPT 741_ AVQQP 746_ STQVP 751_ PSVIQ 756_ QGAPP 761_ SSQVV 766_ PPAQT 771_ GIIHQ 776_ GVQTS 781_ APSLP 786_ QQLVI 791_ ASQSS 796_ LLTVP 801_ PQPQG 806_ VEPVA 811_ QGIVS 816_ QQLPA 821_ VSSLP 826_ SASSI 831_ SVTSQ 836_ VSSTG 841_ PSGMP 846_ SAPTN 851_ LVPPQ 856_ NIAQT 861_ PATQN 866_ GNLVQ 871_ SVSQP 876_ PLIAT 881_ NTNLP 886_ LAQQI 891_ PLSST 896_ QFSAQ 901_ SLAQA 906_ IGSQI 911_ EDARR 916_ AAEPS 921_ LVGLP 926_ QTISG 931_ DSGGM 936_ SAVSD 941_ GSSSS 946_ LAASA 951_ SLFPL 956_ KVLPL 961_ TTPLV 966_ DGEDE 971_ SSSGA 976_ SVVAI 981_ DNKIE 986_ QAMDL 991_ VKSHL 996_ MYAVR 1001_ EEVEV 1006_ LKEQI 1011_ KELIE 1016_ KNSQL 1021_ EQENN 1026_ LLKTL 1031_ ASPEQ 1036_ LAQFQ 1041_ AQLQT 1046_ GSPPA 1051_ TTQPQ 1056_ GTTQP 1061_ PAQPA 1066_SQGSG
1: Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201)
2: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells
3: Positively regulates cell death in response to TGFB3 during mammary gland involution