ELAV-like protein 1 (Hu-antigen R) (HuR)
1_MSNGY 6_ EDHMA 11_ EDCRG 16_ DIGRT 21_ NLIVN 26_ YLPQN 31_ MTQDE 36_ LRSLF 41_ SSIGE 46_ VESAK 51_ LIRDK 56_ VAGHS 61_ LGYGF 66_ VNYVT 71_ AKDAE 76_ RAINT 81_ LNGLR 86_ LQSKT 91_ IKVSY 96_ ARPSS 101_ EVIKD 106_ ANLYI 111_ SGLPR 116_ TMTQK 121_ DVEDM 126_ FSRFG 131_ RIINS 136_ RVLVD 141_ QTTGL 146_ SRGVA 151_ FIRFD 156_ KRSEA 161_ EEAIT 166_ SFNGH 171_ KPPGS 176_ SEPIT 181_ VKFAA 186_ NPNQN 191_ KNVAL 196_ LSQLY 201_ HSPAR 206_ RFGGP 211_ VHHQA 216_ QRFRF 221_ SPMGV 226_ DHMSG 231_ LSGVN 236_ VPGNA 241_ SSGWC 246_ IFIYN 251_ LGQDA 256_ DEGIL 261_ WQMFG 266_ PFGAV 271_ TNVKV 276_ IRDFN 281_ TNKCK 286_ GFGFV 291_ TMTNY 296_ EEAAM 301_ AIASL 306_ NGYRL 311_ GDKIL 316_ QVSFK 321_TNKSH
1: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010)