Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]
1_MNSLV 6_ SWQLL 11_ LFLCA 16_ THFGE 21_ PLEKV 26_ ASVGN 31_ SRPTG 36_ QQLES 41_ LGLLA 46_ PGEQS 51_ LPCTE 56_ RKPAA 61_ TARLS 66_ RRGTS 71_ LSPPP 76_ ESSGS 81_ PQQPG 86_ LSAPH 91_ SRQIP 96_ APQGA 101_ VLVQR 106_ EKDLP 111_ NYNWN 116_ SFGLR 121_ FGKRE 126_ AAPGN 131_HGRSA
1: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood