Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)
1_MEPAV 6_ SEPMR 11_ DQVAR 16_ THLTE 21_ DTPKV 26_ NADIE 31_ KVNQN 36_ QAKRC 41_ TVIGG 46_ SGFLG 51_ QHMVE 56_ QLLAR 61_ GYAVN 66_ VFDIQ 71_ QGFDN 76_ PQVRF 81_ FLGDL 86_ CSRQD 91_ LYPAL 96_ KGVNT 101_ VFHCA 106_ SPPPS 111_ SNNKE 116_ LFYRV 121_ NYIGT 126_ KNVIE 131_ TCKEA 136_ GVQKL 141_ ILTSS 146_ ASVIF 151_ EGVDI 156_ KNGTE 161_ DLPYA 166_ MKPID 171_ YYTET 176_ KILQE 181_ RAVLG 186_ ANDPE 191_ KNFLT 196_ TAIRP 201_ HGIFG 206_ PRDPQ 211_ LVPIL 216_ IEAAR 221_ NGKMK 226_ FVIGN 231_ GKNLV 236_ DFTFV 241_ ENVVH 246_ GHILA 251_ AEQLS 256_ RDSTL 261_ GGKAF 266_ HITND 271_ EPIPF 276_ WTFLS 281_ RILTG 286_ LNYEA 291_ PKYHI 296_ PYWVA 301_ YYLAL 306_ LLSLL 311_ VMVIS 316_ PVIQL 321_ QPTFT 326_ PMRVA 331_ LAGTF 336_ HYYSC 341_ ERAKK 346_ AMGYQ 351_ PLVTM 356_ DDAME 361_ RTVQS 366_FRHLR
1: Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity)