Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]
1_MGDVK 6_ LVASS 11_ HISKT 16_ SLSVD 21_ PSRVD 26_ SMPLT 31_ EAPAF 36_ ILPPR 41_ NLCIK 46_ EGATA 51_ KFEGR 56_ VRGYP 61_ EPQVT 66_ WHRNG 71_ QPITS 76_ GGRFL 81_ LDCGI 86_ RGTFS 91_ LVIHA 96_ VHEED 101_ RGKYT 106_ CEATN 111_ GSGAR 116_ QVTVE 121_ LTVEG 126_ SFAKQ 131_ LGQPV 136_ VSKTL 141_ GDRFS 146_ APAVE 151_ TRPSI 156_ WGECP 161_ PKFAT 166_ KLGRV 171_ VVKEG 176_ QMGRF 181_ SCKIT 186_ GRPQP 191_ QVTWL 196_ KGNVP 201_ LQPSA 206_ RVSVS 211_ EKNGM 216_ QVLEI 221_ HGVNQ 226_ DDVGV 231_ YTCLV 236_ VNGSG 241_ KASMS 246_ AELSI 251_ QGLDS 256_ ANRSF 261_ VRETK 266_ ATNSD 271_ VRKEV 276_ TNVIS 281_ KESKL 286_ DSLEA 291_ AAKSK 296_ NCSSP 301_ QRGGS 306_ PPWAA 311_ NSQPQ 316_ PPRES 321_ KLESC 326_ KDSPR 331_ TAPQT 336_ PVLQK 341_ TSSSI 346_ TLQAA 351_ RVQPE 356_ PRAPG 361_ LGVLS 366_ PSGEE 371_ RKRPA 376_ PPRPA 381_ TFPTR 386_ QPGLG 391_ SQDVV 396_ SKAAN 401_ RRIPM 406_ EGQRD 411_ SAFPK 416_ FESKP 421_ QSQEV 426_ KENQT 431_ VKFRC 436_ EVSGI 441_ PKPEV 446_ AWFLE 451_ GTPVR 456_ RQEGS 461_ IEVYE 466_ DAGSH 471_ YLCLL 476_ KARTR 481_ DSGTY 486_ SCTAS 491_ NAQGQ 496_ LSCSW 501_ TLQVE 506_ RLAVM 511_ EVAPS 516_ FSSVL 521_ KDCAV 526_ IEGQD 531_ FVLQC 536_ SVRGT 541_ PVPRI 546_ TWLLN 551_ GQPIQ 556_ YARST 561_ CEAGV 566_ AELHI 571_ QDALP 576_ EDHGT 581_ YTCLA 586_ ENALG 591_ QVSCS 596_ AWVTV 601_ HEKKS 606_ SRKSE 611_ YLLPV 616_ APSKP 621_ TAPIF 626_ LQGLS 631_ DLKVM 636_ DGSQV 641_ TMTVQ 646_ VSGNP 651_ PPEVI 656_ WLHNG 661_ NEIQE 666_ SEDFH 671_ FEQRG 676_ TQHSL 681_ CIQEV 686_ FPEDT 691_ GTYTC 696_ EAWNS 701_ AGEVR 706_ TQAVL 711_ TVQEP 716_ HDGTQ 721_ PWFIS 726_ KPRSV 731_ TASLG 736_ QSVLI 741_ SCAIA 746_ GDPFP 751_ TVHWL 756_ RDGKA 761_ LCKDT 766_ GHFEV 771_ LQNED 776_ VFTLV 781_ LKKVQ 786_ PWHAG 791_ QYEIL 796_ LKNRV 801_ GECSC 806_ QVSLM 811_ LQNSS 816_ ARALP 821_ RGREP 826_ ASCED 831_ LCGGG 836_ VGADG 841_ GGSDR 846_ YGSLR 851_ PGWPA 856_ RGQGW 861_ LEEED 866_ GEDVR 871_ GVLKR 876_ RVETR 881_ QHTEE 886_ AIRQQ 891_ EVEQL 896_ DFRDL 901_ LGKKV 906_ STKTL 911_ SEDDL 916_ KEIPA 921_ EQMDF 926_ RANLQ 931_ RQVKP 936_ KTVSE 941_ EERKV 946_ HSPQQ 951_ VDFRS 956_ VLAKK 961_ GTSKT 966_ PVPEK 971_ VPPPK 976_ PATPD 981_ FRSVL 986_ GGKKK 991_ LPAEN 996_ GSSSA 1001_ ETLNA 1006_ KAVES 1011_ SKPLS 1016_ NAQPS 1021_ GPLKP 1026_ VGNAK 1031_ PAETL 1036_ KPMGN 1041_ AKPAE 1046_ TLKPM 1051_ GNAKP 1056_ DENLK 1061_ SASKE 1066_ ELKKD 1071_ VKNDV 1076_ NCKRG 1081_ HAGTT 1086_ DNEKR 1091_ SESQG 1096_ TAPAF 1101_ KQKLQ 1106_ DVHVA 1111_ EGKKL 1116_ LLQCQ 1121_ VSSDP 1126_ PATII 1131_ WTLNG 1136_ KTLKT 1141_ TKFII 1146_ LSQEG 1151_ SLCSV 1156_ SIEKA 1161_ LPEDR 1166_ GLYKC 1171_ VAKND 1176_ AGQAE 1181_ CSCQV 1186_ TVDDA 1191_ PASEN 1196_ TKAPE 1201_ MKSRR 1206_ PKSSL 1211_ PPVLG 1216_ TESDA 1221_ TVKKK 1226_ PAPKT 1231_ PPKAA 1236_ MPPQI 1241_ IQFPE 1246_ DQKVR 1251_ AGESV 1256_ ELFGK 1261_ VTGTQ 1266_ PITCT 1271_ WMKFR 1276_ KQIQE 1281_ SEHMK 1286_ VENSE 1291_ NGSKL 1296_ TILAA 1301_ RQEHC 1306_ GCYTL 1311_ LVENK 1316_ LGSRQ 1321_ AQVNL 1326_ TVVDK 1331_ PDPPA 1336_ GTPCA 1341_ SDIRS 1346_ SSLTL 1351_ SWYGS 1356_ SYDGG 1361_ SAVQS 1366_ YSIEI 1371_ WDSAN 1376_ KTWKE 1381_ LATCR 1386_ STSFN 1391_ VQDLL 1396_ PDHEY 1401_ KFRVR 1406_ AINVY 1411_ GTSEP 1416_ SQESE 1421_ LTTVG 1426_ EKPEE 1431_ PKDEV 1436_ EVSDD 1441_ DEKEP 1446_ EVDYR 1451_ TVTIN 1456_ TEQKV 1461_ SDFYD 1466_ IEERL 1471_ GSGKF 1476_ GQVFR 1481_ LVEKK 1486_ TRKVW 1491_ AGKFF 1496_ KAYSA 1501_ KEKEN 1506_ IRQEI 1511_ SIMNC 1516_ LHHPK 1521_ LVQCV 1526_ DAFEE 1531_ KANIV 1536_ MVLEI 1541_ VSGGE 1546_ LFERI 1551_ IDEDF 1556_ ELTER 1561_ ECIKY 1566_ MRQIS 1571_ EGVEY 1576_ IHKQG 1581_ IVHLD 1586_ LKPEN 1591_ IMCVN 1596_ KTGTR 1601_ IKLID 1606_ FGLAR 1611_ RLENA 1616_ GSLKV 1621_ LFGTP 1626_ EFVAP 1631_ EVINY 1636_ EPIGY 1641_ ATDMW 1646_ SIGVI 1651_ CYILV 1656_ SGLSP 1661_ FMGDN 1666_ DNETL 1671_ ANVTS 1676_ ATWDF 1681_ DDEAF 1686_ DEISD 1691_ DAKDF 1696_ ISNLL 1701_ KKDMK 1706_ NRLDC 1711_ TQCLQ 1716_ HPWLM 1721_ KDTKN 1726_ MEAKK 1731_ LSKDR 1736_ MKKYM 1741_ ARRKW 1746_ QKTGN 1751_ AVRAI 1756_ GRLSS 1761_ MAMIS 1766_ GLSGR 1771_ KSSTG 1776_ SPTSP 1781_ LNAEK 1786_ LESEE 1791_ DVSQA 1796_ FLEAV 1801_ AEEKP 1806_ HVKPY 1811_ FSKTI 1816_ RDLEV 1821_ VEGSA 1826_ ARFDC 1831_ KIEGY 1836_ PDPEV 1841_ VWFKD 1846_ DQSIR 1851_ ESRHF 1856_ QIDYD 1861_ EDGNC 1866_ SLIIS 1871_ DVCGD 1876_ DDAKY 1881_ TCKAV 1886_ NSLGE 1891_ ATCTA 1896_ ELIVE 1901_ TMEEG 1906_EGEGE
1: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis