TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)
1_MAAQR 6_ RSLLQ 11_ SEQQP 16_ SWTDD 21_ LPLCH 26_ LSGVG 31_ SASNR 36_ SYSAD 41_ GKGTE 46_ SHPPE 51_ DSWLK 56_ FRSEN 61_ NCFLY 66_ GVFNG 71_ YDGNR 76_ VTNFV 81_ AQRLS 86_ AELLL 91_ GQLNA 96_ EHAEA 101_ DVRRV 106_ LLQAF 111_ DVVER 116_ SFLES 121_ IDDAL 126_ AEKAS 131_ LQSQL 136_ PEGVP 141_ QHQLP 146_ PQYQK 151_ ILERL 156_ KTLER 161_ EISGG 166_ AMAVV 171_ AVLLN 176_ NKLYV 181_ ANVGT 186_ NRALL 191_ CKSTV 196_ DGLQV 201_ TQLNV 206_ DHTTE 211_ NEDEL 216_ FRLSQ 221_ LGLDA 226_ GKIKQ 231_ VGIIC 236_ GQEST 241_ RRIGD 246_ YKVKY 251_ GYTDI 256_ DLLSA 261_ AKSKP 266_ IIAEP 271_ EIHGA 276_ QPLDG 281_ VTGFL 286_ VLMSE 291_ GLYKA 296_ LEAAH 301_ GPGQA 306_ NQEIA 311_ AMIDT 316_ EFAKQ 321_ TSLDA 326_ VAQAV 331_ VDRVK 336_ RIHSD 341_ TFASG 346_ GERAR 351_ FCPRH 356_ EDMTL 361_ LVRNF 366_ GYPLG 371_ EMSQP 376_ TPSPA 381_ PAAGG 386_ RVYPV 391_ SVPYS 396_ SAQST 401_ SKTSV 406_ TLSLV 411_ MPSQG 416_ QMVNG 421_ AHSAS 426_ TLDEA 431_ TPTLT 436_ NQSPT 441_ LTLQS 446_ TNTHT 451_ QSSSS 456_ SSDGG 461_ LFRSR 466_ PAHSL 471_ PPGED 476_ GRVEP 481_ YVDFA 486_ EFYRL 491_ WSVDH 496_GEQSV
1: Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073)