Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)
1_MVADP 6_ PRDSK 11_ GLAAA 16_ EPTAN 21_ GGLAL 26_ ASIED 31_ QGAAA 36_ GGYCG 41_ SRDQV 46_ RRCLR 51_ ANLLV 56_ LLTVV 61_ AVVAG 66_ VALGL 71_ GVSGA 76_ GGALA 81_ LGPER 86_ LSAFV 91_ FPGEL 96_ LLRLL 101_ RMIIL 106_ PLVVC 111_ SLIGG 116_ AASLD 121_ PGALG 126_ RLGAW 131_ ALLFF 136_ LVTTL 141_ LASAL 146_ GVGLA 151_ LALQP 156_ GAASA 161_ AINAS 166_ VGAAG 171_ SAENA 176_ PSKEV 181_ LDSFL 186_ DLARN 191_ IFPSN 196_ LVSAA 201_ FRSYS 206_ TTYEE 211_ RNITG 216_ TRVKV 221_ PVGQE 226_ VEGMN 231_ ILGLV 236_ VFAIV 241_ FGVAL 246_ RKLGP 251_ EGELL 256_ IRFFN 261_ SFNEA 266_ TMVLV 271_ SWIMW 276_ YAPVG 281_ IMFLV 286_ AGKIV 291_ EMEDV 296_ GLLFA 301_ RLGKY 306_ ILCCL 311_ LGHAI 316_ HGLLV 321_ LPLIY 326_ FLFTR 331_ KNPYR 336_ FLWGI 341_ VTPLA 346_ TAFGT 351_ SSSSA 356_ TLPLM 361_ MKCVE 366_ ENNGV 371_ AKHIS 376_ RFILP 381_ IGATV 386_ NMDGA 391_ ALFQC 396_ VAAVF 401_ IAQLS 406_ QQSLD 411_ FVKII 416_ TILVT 421_ ATASS 426_ VGAAG 431_ IPAGG 436_ VLTLA 441_ IILEA 446_ VNLPV 451_ DHISL 456_ ILAVD 461_ WLVDR 466_ SCTVL 471_ NVEGD 476_ ALGAG 481_ LLQNY 486_ VDRTE 491_ SRSTE 496_ PELIQ 501_ VKSEL 506_ PLDPL 511_ PVPTE 516_ EGNPL 521_ LKHYR 526_ GPAGD 531_ ATVAS 536_EKESV
1: Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904)
2: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114
3: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus
4: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses