Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)
1_MGPPH 6_ SGPGG 11_ VRVGA 16_ LLLLG 21_ VLGLV 26_ SGLSL 31_ EPVYW 36_ NSANK 41_ RFQAE 46_ GGYVL 51_ YPQIG 56_ DRLDL 61_ LCPRA 66_ RPPGP 71_ HSSPN 76_ YEFYK 81_ LYLVG 86_ GAQGR 91_ RCEAP 96_ PAPNL 101_ LLTCD 106_ RPDLD 111_ LRFTI 116_ KFQEY 121_ SPNLW 126_ GHEFR 131_ SHHDY 136_ YIIAT 141_ SDGTR 146_ EGLES 151_ LQGGV 156_ CLTRG 161_ MKVLL 166_ RVGQS 171_ PRGGA 176_ VPRKP 181_ VSEMP 186_ MERDR 191_ GAAHS 196_ LEPGK 201_ ENLPG 206_ DPTSN 211_ ATSRG 216_ AEGPL 221_ PPPSM 226_ PAVAG 231_ AAGGL 236_ ALLLL 241_ GVAGA 246_ GGAMC 251_ WRRRR 256_ AKPSE 261_ SRHPG 266_ PGSFG 271_ RGGSL 276_ GLGGG 281_ GGMGP 286_ REAEP 291_ GELGI 296_ ALRGG 301_ GAADP 306_ PFCPH 311_ YEKVS 316_ GDYGH 321_ PVYIV 326_ QDGPP 331_QSPPN
1: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity)
2: (Microbial infection) Acts as a receptor for nipah virus and hendra virus