Ras-related protein Rab-30
1_MSMED 6_ YDFLF 11_ KIVLI 16_ GNAGV 21_ GKTCL 26_ VRRFT 31_ QGLFP 36_ PGQGA 41_ TIGVD 46_ FMIKT 51_ VEING 56_ EKVKL 61_ QIWDT 66_ AGQER 71_ FRSIT 76_ QSYYR 81_ SANAL 86_ ILTYD 91_ ITCEE 96_ SFRCL 101_ PEWLR 106_ EIEQY 111_ ASNKV 116_ ITVLV 121_ GNKID 126_ LAERR 131_ EVSQQ 136_ RAEEF 141_ SEAQD 146_ MYYLE 151_ TSAKE 156_ SDNVE 161_ KLFLD 166_ LACRL 171_ ISEAR 176_ QNTLV 181_ NNVSS 186_ PLPGE 191_ GKSIS 196_YLTCC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875)