Neurogenic differentiation factor 2 (NeuroD2) (Class A basic helix-loop-helix protein 1) (bHLHa1) (NeuroD-related factor) (NDRF)
1_MLTRL 6_ FSEPG 11_ LLSDV 16_ PKFAS 21_ WGDGE 26_ DDEPR 31_ SDKGD 36_ APPPP 41_ PPAPG 46_ PGAPG 51_ PARAA 56_ KPVPL 61_ RGEEG 66_ TEATL 71_ AEVKE 76_ EGELG 81_ GEEEE 86_ EEEEE 91_ EGLDE 96_ AEGER 101_ PKKRG 106_ PKKRK 111_ MTKAR 116_ LERSK 121_ LRRQK 126_ ANARE 131_ RNRMH 136_ DLNAA 141_ LDNLR 146_ KVVPC 151_ YSKTQ 156_ KLSKI 161_ ETLRL 166_ AKNYI 171_ WALSE 176_ ILRSG 181_ KRPDL 186_ VSYVQ 191_ TLCKG 196_ LSQPT 201_ TNLVA 206_ GCLQL 211_ NSRNF 216_ LTEQG 221_ ADGAG 226_ RFHGS 231_ GGPFA 236_ MHPYP 241_ YPCSR 246_ LAGAQ 251_ CQAAG 256_ GLGGG 261_ AAHAL 266_ RTHGY 271_ CAAYE 276_ TLYAA 281_ AGGGG 286_ ASPDY 291_ NSSEY 296_ EGPLS 301_ PPLCL 306_ NGNFS 311_ LKQDS 316_ SPDHE 321_ KSYHY 326_ SMHYS 331_ ALPGS 336_ RPTGH 341_ GLVFG 346_ SSAVR 351_ GGVHS 356_ ENLLS 361_ YDMHL 366_ HHDRG 371_ PMYEE 376_LNAFF
1: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity)