Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
1_MSGLG 6_ DSSSD 11_ PANPD 16_ SHKRK 21_ GSPCD 26_ TLASS 31_ TEKRR 36_ REQEN 41_ KYLEE 46_ LAELL 51_ SANIS 56_ DIDSL 61_ SVKPD 66_ KCKIL 71_ KKTVD 76_ QIQLM 81_ KRMEQ 86_ EKSTT 91_ DDDVQ 96_ KSDIS 101_ SSSQG 106_ VIEKE 111_ SLGPL 116_ LLEAL 121_ DGFFF 126_ VVNCE 131_ GRIVF 136_ VSENV 141_ TSYLG 146_ YNQEE 151_ LMNTS 156_ VYSIL 161_ HVGDH 166_ AEFVK 171_ NLLPK 176_ SLVNG 181_ VPWPQ 186_ EATRR 191_ NSHTF 196_ NCRML 201_ IHPPD 206_ EPGTE 211_ NQEAC 216_ QRYEV 221_ MQCFT 226_ VSQPK 231_ SIQED 236_ GEDFQ 241_ SCLIC 246_ IARRL 251_ PRPPA 256_ ITGVE 261_ SFMTK 266_ QDTTG 271_ KIISI 276_ DTSSL 281_ RAAGR 286_ TGWED 291_ LVRKC 296_ IYAFF 301_ QPQGR 306_ EPSYA 311_ RQLFQ 316_ EVMTR 321_ GTASS 326_ PSYRF 331_ ILNDG 336_ TMLSA 341_ HTKCK 346_ LCYPQ 351_ SPDMQ 356_ PFIMG 361_ IHIID 366_ REHSG 371_ LSPQD 376_ DTNSG 381_ MSIPR 386_ VNPSV 391_ NPSIS 396_ PAHGV 401_ ARSST 406_ LPPSN 411_ SNMVS 416_ TRINR 421_ QQSSD 426_ LHSSS 431_ HSNSS 436_ NSQGS 441_ FGCSP 446_ GSQIV 451_ ANVAL 456_ NQGQA 461_ SSQSS 466_ NPSLN 471_ LNNSP 476_ MEGTG 481_ ISLAQ 486_ FMSPR 491_ RQVTS 496_ GLATR 501_ PRMPN 506_ NSFPP 511_ NISTL 516_ SSPVG 521_ MTSSA 526_ CNNNN 531_ RSYSN 536_ IPVTS 541_ LQGMN 546_ EGPNN 551_ SVGFS 556_ ASSPV 561_ LRQMS 566_ SQNSP 571_ SRLNI 576_ QPAKA 581_ ESKDN 586_ KEIAS 591_ ILNEM 596_ IQSDN 601_ SSSDG 606_ KPLDS 611_ GLLHN 616_ NDRLS 621_ DGDSK 626_ YSQTS 631_ HKLVQ 636_ LLTTT 641_ AEQQL 646_ RHADI 651_ DTSCK 656_ DVLSC 661_ TGTSN 666_ SASAN 671_ SSGGS 676_ CPSSH 681_ SSLTE 686_ RHKIL 691_ HRLLQ 696_ EGSPS 701_ DITTL 706_ SVEPD 711_ KKDSA 716_ STSVS 721_ VTGQV 726_ QGNSS 731_ IKLEL 736_ DASKK 741_ KESKD 746_ HQLLR 751_ YLLDK 756_ DEKDL 761_ RSTPN 766_ LSLDD 771_ VKVKV 776_ EKKEQ 781_ MDPCN 786_ TNPTP 791_ MTKPT 796_ PEEIK 801_ LEAQS 806_ QFTAD 811_ LDQFD 816_ QLLPT 821_ LEKAA 826_ QLPGL 831_ CETDR 836_ MDGAV 841_ TSVTI 846_ KSEIL 851_ PASLQ 856_ SATAR 861_ PTSRL 866_ NRLPE 871_ LELEA 876_ IDNQF 881_ GQPGT 886_ GDQIP 891_ WTNNT 896_ VTAIN 901_ QSKSE 906_ DQCIS 911_ SQLDE 916_ LLCPP 921_ TTVEG 926_ RNDEK 931_ ALLEQ 936_ LVSFL 941_ SGKDE 946_ TELAE 951_ LDRAL 956_ GIDKL 961_ VQGGG 966_ LDVLS 971_ ERFPP 976_ QQATP 981_ PLIME 986_ ERPNL 991_ YSQPY 996_ SSPSP 1001_ TANLP 1006_ SPFQG 1011_ MVRQK 1016_ PSLGT 1021_ MPVQV 1026_ TPPRG 1031_ AFSPG 1036_ MGMQP 1041_ RQTLN 1046_ RPPAA 1051_ PNQLR 1056_ LQLQQ 1061_ RLQGQ 1066_ QQLIH 1071_ QNRQA 1076_ ILNQF 1081_ AATAP 1086_ VGINM 1091_ RSGMQ 1096_ QQITP 1101_ QPPLN 1106_ AQMLA 1111_ QRQRE 1116_ LYSQQ 1121_ HRQRQ 1126_ LIQQQ 1131_ RAMLM 1136_ RQQSF 1141_ GNNLP 1146_ PSSGL 1151_ PVQMG 1156_ NPRLP 1161_ QGAPQ 1166_ QFPYP 1171_ PNYGT 1176_ NPGTP 1181_ PASTS 1186_ PFSQL 1191_ AANPE 1196_ ASLAN 1201_ RNSMV 1206_ SRGMT 1211_ GNIGG 1216_ QFGTG 1221_ INPQM 1226_ QQNVF 1231_ QYPGA 1236_ GMVPQ 1241_ GEANF 1246_ APSLS 1251_ PGSSM 1256_ VPMPI 1261_ PPPQS 1266_ SLLQQ 1271_ TPPAS 1276_ GYQSP 1281_ DMKAW 1286_ QQGAI 1291_ GNNNV 1296_ FSQAV 1301_ QNQPT 1306_ PAQPG 1311_ VYNNM 1316_ SITVS 1321_ MAGGN 1326_ TNVQN 1331_ MNPMM 1336_ AQMQM 1341_ SSLQM 1346_ PGMNT 1351_ VCPEQ 1356_ INDPA 1361_ LRHTG 1366_ LYCNQ 1371_ LSSTD 1376_ LLKTE 1381_ ADGTQ 1386_ QVQQV 1391_ QVFAD 1396_ VQCTV 1401_ NLVGG 1406_ DPYLN 1411_ QPGPL 1416_ GTQKP 1421_ TSGPQ 1426_ TPQAQ 1431_ QKSLL 1436_QQLLT
1: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3