Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
1_MSSIL 6_ PFTPP 11_ VVKRL 16_ LGWKK 21_ SAGGS 26_ GGAGG 31_ GEQNG 36_ QEEKW 41_ CEKAV 46_ KSLVK 51_ KLKKT 56_ GRLDE 61_ LEKAI 66_ TTQNC 71_ NTKCV 76_ TIPST 81_ CSEIW 86_ GLSTP 91_ NTIDQ 96_ WDTTG 101_ LYSFS 106_ EQTRS 111_ LDGRL 116_ QVSHR 121_ KGLPH 126_ VIYCR 131_ LWRWP 136_ DLHSH 141_ HELKA 146_ IENCE 151_ YAFNL 156_ KKDEV 161_ CVNPY 166_ HYQRV 171_ ETPVL 176_ PPVLV 181_ PRHTE 186_ ILTEL 191_ PPLDD 196_ YTHSI 201_ PENTN 206_ FPAGI 211_ EPQSN 216_ YIPET 221_ PPPGY 226_ ISEDG 231_ ETSDQ 236_ QLNQS 241_ MDTGS 246_ PAELS 251_ PTTLS 256_ PVNHS 261_ LDLQP 266_ VTYSE 271_ PAFWC 276_ SIAYY 281_ ELNQR 286_ VGETF 291_ HASQP 296_ SLTVD 301_ GFTDP 306_ SNSER 311_ FCLGL 316_ LSNVN 321_ RNATV 326_ EMTRR 331_ HIGRG 336_ VRLYY 341_ IGGEV 346_ FAECL 351_ SDSAI 356_ FVQSP 361_ NCNQR 366_ YGWHP 371_ ATVCK 376_ IPPGC 381_ NLKIF 386_ NNQEF 391_ AALLA 396_ QSVNQ 401_ GFEAV 406_ YQLTR 411_ MCTIR 416_ MSFVK 421_ GWGAE 426_ YRRQT 431_ VTSTP 436_ CWIEL 441_ HLNGP 446_ LQWLD 451_ KVLTQ 456_ MGSPS 461_VRCSS
1: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209)