Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
1_MNVTS 6_ LFSFT 11_ SPAVK 16_ RLLGW 21_ KQGDE 26_ EEKWA 31_ EKAVD 36_ ALVKK 41_ LKKKK 46_ GAMEE 51_ LEKAL 56_ SCPGQ 61_ PSNCV 66_ TIPRS 71_ LDGRL 76_ QVSHR 81_ KGLPH 86_ VIYCR 91_ VWRWP 96_ DLQSH 101_ HELKP 106_ LECCE 111_ FPFGS 116_ KQKEV 121_ CINPY 126_ HYKRV 131_ ESPVL 136_ PPVLV 141_ PRHSE 146_ YNPQH 151_ SLLAQ 156_ FRNLG 161_ QNEPH 166_ MPLNA 171_ TFPDS 176_ FQQPN 181_ SHPFP 186_ HSPNS 191_ SYPNS 196_ PGSSS 201_ STYPH 206_ SPTSS 211_ DPGSP 216_ FQMPA 221_ DTPPP 226_ AYLPP 231_ EDPMT 236_ QDGSQ 241_ PMDTN 246_ MMAPP 251_ LPSEI 256_ NRGDV 261_ QAVAY 266_ EEPKH 271_ WCSIV 276_ YYELN 281_ NRVGE 286_ AFHAS 291_ STSVL 296_ VDGFT 301_ DPSNN 306_ KNRFC 311_ LGLLS 316_ NVNRN 321_ STIEN 326_ TRRHI 331_ GKGVH 336_ LYYVG 341_ GEVYA 346_ ECLSD 351_ SSIFV 356_ QSRNC 361_ NYHHG 366_ FHPTT 371_ VCKIP 376_ SGCSL 381_ KIFNN 386_ QEFAQ 391_ LLAQS 396_ VNHGF 401_ ETVYE 406_ LTKMC 411_ TIRMS 416_ FVKGW 421_ GAEYH 426_ RQDVT 431_ STPCW 436_ IEIHL 441_ HGPLQ 446_ WLDKV 451_ LTQMG 456_SPHNP
1: Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity)