Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
1_MAQFP 6_ TPFGG 11_ SLDIW 16_ AITVE 21_ ERAKH 26_ DQQFH 31_ SLKPI 36_ SGFIT 41_ GDQAR 46_ NFFFQ 51_ SGLPQ 56_ PVLAQ 61_ IWALA 66_ DMNND 71_ GRMDQ 76_ VEFSI 81_ AMKLI 86_ KLKLQ 91_ GYQLP 96_ SALPP 101_ VMKQQ 106_ PVAIS 111_ SAPAF 116_ GMGGI 121_ ASMPP 126_ LTAVA 131_ PVPMG 136_ SIPVV 141_ GMSPT 146_ LVSSV 151_ PTAAV 156_ PPLAN 161_ GAPPV 166_ IQPLP 171_ AFAHP 176_ AATLP 181_ KSSSF 186_ SRSGP 191_ GSQLN 196_ TKLQK 201_ AQSFD 206_ VASVP 211_ PVAEW 216_ AVPQS 221_ SRLKY 226_ RQLFN 231_ SHDKT 236_ MSGHL 241_ TGPQA 246_ RTILM 251_ QSSLP 256_ QAQLA 261_ SIWNL 266_ SDIDQ 271_ DGKLT 276_ AEEFI 281_ LAMHL 286_ IDVAM 291_ SGQPL 296_ PPVLP 301_ PEYIP 306_ PSFRR 311_ VRSGS 316_ GISVI 321_ SSTSV 326_ DQRLP 331_ EEPVL 336_ EDEQQ 341_ QLEKK 346_ LPVTF 351_ EDKKR 356_ ENFER 361_ GNLEL 366_ EKRRQ 371_ ALLEQ 376_ QRKEQ 381_ ERLAQ 386_ LERAE 391_ QERKE 396_ RERQE 401_ QERKR 406_ QLELE 411_ KQLEK 416_ QRELE 421_ RQREE 426_ ERRKE 431_ IERRE 436_ AAKRE 441_ LERQR 446_ QLEWE 451_ RNRRQ 456_ ELLNQ 461_ RNKEQ 466_ EDIVV 471_ LKAKK 476_ KTLEF 481_ ELEAL 486_ NDKKH 491_ QLEGK 496_ LQDIR 501_ CRLTT 506_ QRQEI 511_ ESTNK 516_ SRELR 521_ IAEIT 526_ HLQQQ 531_ LQESQ 536_ QMLGR 541_ LIPEK 546_ QILND 551_ QLKQV 556_ QQNSL 561_ HRDSL 566_ VTLKR 571_ ALEAK 576_ ELARQ 581_ HLRDQ 586_ LDEVE 591_ KETRS 596_ KLQEI 601_ DIFNN 606_ QLKEL 611_ REIHN 616_ KQQLQ 621_ KQKSM 626_ EAERL 631_ KQKEQ 636_ ERKII 641_ ELEKQ 646_ KEEAQ 651_ RRAQE 656_ RDKQW 661_ LEHVQ 666_ QEDEH 671_ QRPRK 676_ LHEEE 681_ KLKRE 686_ ESVKK 691_ KDGEE 696_ KGKQE 701_ AQDKL 706_ GRLFH 711_ QHQEP 716_ AKPAV 721_ QAPWS 726_ TAEKG 731_ PLTIS 736_ AQENV 741_ KVVYY 746_ RALYP 751_ FESRS 756_ HDEIT 761_ IQPGD 766_ IVMVK 771_ GEWVD 776_ ESQTG 781_ EPGWL 786_ GGELK 791_ GKTGW 796_ FPANY 801_ AEKIP 806_ ENEVP 811_ APVKP 816_ VTDST 821_ SAPAP 826_ KLALR 831_ ETPAP 836_ LAVTS 841_ SEPST 846_ TPNNW 851_ ADFSS 856_ TWPTS 861_ TNEKP 866_ ETDNW 871_ DAWAA 876_ QPSLT 881_ VPSAG 886_ QLRQR 891_ SAFTP 896_ ATATG 901_ SSPSP 906_ VLGQG 911_ EKVEG 916_ LQAQA 921_ LYPWR 926_ AKKDN 931_ HLNFN 936_ KNDVI 941_ TVLEQ 946_ QDMWW 951_ FGEVQ 956_ GQKGW 961_ FPKSY 966_ VKLIS 971_ GPIRK 976_ STSMD 981_ SGSSE 986_ SPASL 991_ KRVAS 996_ PAAKP 1001_ VVSGE 1006_ EFIAM 1011_ YTYES 1016_ SEQGD 1021_ LTFQQ 1026_ GDVIL 1031_ VTKKD 1036_ GDWWT 1041_ GTVGD 1046_ KAGVF 1051_ PSNYV 1056_ RLKDS 1061_ EGSGT 1066_ AGKTG 1071_ SLGKK 1076_ PEIAQ 1081_ VIASY 1086_ TATGP 1091_ EQLTL 1096_ APGQL 1101_ ILIRK 1106_ KNPGG 1111_ WWEGE 1116_ LQARG 1121_ KKRQI 1126_ GWFPA 1131_ NYVKL 1136_ LSPGT 1141_ SKITP 1146_ TEPPK 1151_ STALA 1156_ AVCQV 1161_ IGMYD 1166_ YTAQN 1171_ DDELA 1176_ FNKGQ 1181_ IINVL 1186_ NKEDP 1191_ DWWKG 1196_ EVNGQ 1201_ VGLFP 1206_ SNYVK 1211_ LTTDM 1216_ DPSQQ 1221_ WCSDL 1226_ HLLDM 1231_ LTPTE 1236_ RKRQG 1241_ YIHEL 1246_ IVTEE 1251_ NYVND 1256_ LQLVT 1261_ EIFQK 1266_ PLMES 1271_ ELLTE 1276_ KEVAM 1281_ IFVNW 1286_ KELIM 1291_ CNIKL 1296_ LKALR 1301_ VRKKM 1306_ SGEKM 1311_ PVKMI 1316_ GDILS 1321_ AQLPH 1326_ MQPYI 1331_ RFCSR 1336_ QLNGA 1341_ ALIQQ 1346_ KTDEA 1351_ PDFKE 1356_ FVKRL 1361_ AMDPR 1366_ CKGMP 1371_ LSSFI 1376_ LKPMQ 1381_ RVTRY 1386_ PLIIK 1391_ NILEN 1396_ TPENH 1401_ PDHSH 1406_ LKHAL 1411_ EKAEE 1416_ LCSQV 1421_ NEGVR 1426_ EKENS 1431_ DRLEW 1436_ IQAHV 1441_ QCEGL 1446_ SEQLV 1451_ FNSVT 1456_ NCLGP 1461_ RKFLH 1466_ SGKLY 1471_ KAKSN 1476_ KELYG 1481_ FLFND 1486_ FLLLT 1491_ QITKP 1496_ LGSSG 1501_ TDKVF 1506_ SPKSN 1511_ LQYKM 1516_ YKTPI 1521_ FLNEV 1526_ LVKLP 1531_ TDPSG 1536_ DEPIF 1541_ HISHI 1546_ DRVYT 1551_ LRAES 1556_ INERT 1561_ AWVQK 1566_ IKAAS 1571_ ELYIE 1576_ TEKKK 1581_ REKAY 1586_ LVRSQ 1591_ RATGI 1596_ GRLMV 1601_ NVVEG 1606_ IELKP 1611_ CRSHG 1616_ KSNPY 1621_ CEVTM 1626_ GSQCH 1631_ ITKTI 1636_ QDTLN 1641_ PKWNS 1646_ NCQFF 1651_ IRDLE 1656_ QEVLC 1661_ ITVFE 1666_ RDQFS 1671_ PDDFL 1676_ GRTEI 1681_ RVADI 1686_ KKDQG 1691_ SKGPV 1696_ TKCLL 1701_ LHEVP 1706_ TGEIV 1711_ VRLDL 1716_QLFDE
1: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688)
2: Plays a role in synaptic vesicle endocytosis in brain neurons