Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
1_MAVST 6_ GVKVP 11_ RNFRL 16_ LEELE 21_ EGQKG 26_ VGDGT 31_ VSWGL 36_ EDDED 41_ MTLTR 46_ WTGMI 51_ IGPPR 56_ TNYEN 61_ RIYSL 66_ KVECG 71_ PKYPE 76_ APPSV 81_ RFVTK 86_ INMNG 91_ INNSS 96_ GMVDA 101_ RSIPV 106_ LAKWQ 111_ NSYSI 116_ KVVLQ 121_ ELRRL 126_ MMSKE 131_ NMKLP 136_QPPEG
1: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage