Neuronal acetylcholine receptor subunit alpha-2
1_MGPSC 6_ PVFLS 11_ FTKLS 16_ LWWLL 21_ LTPAG 26_ GEEAK 31_ RPPPR 36_ APGDP 41_ LSSPS 46_ PTALP 51_ QGGSH 56_ TETED 61_ RLFKH 66_ LFRGY 71_ NRWAR 76_ PVPNT 81_ SDVVI 86_ VRFGL 91_ SIAQL 96_ IDVDE 101_ KNQMM 106_ TTNVW 111_ LKQEW 116_ SDYKL 121_ RWNPT 126_ DFGNI 131_ TSLRV 136_ PSEMI 141_ WIPDI 146_ VLYNN 151_ ADGEF 156_ AVTHM 161_ TKAHL 166_ FSTGT 171_ VHWVP 176_ PAIYK 181_ SSCSI 186_ DVTFF 191_ PFDQQ 196_ NCKMK 201_ FGSWT 206_ YDKAK 211_ IDLEQ 216_ MEQTV 221_ DLKDY 226_ WESGE 231_ WAIVN 236_ ATGTY 241_ NSKKY 246_ DCCAE 251_ IYPDV 256_ TYAFV 261_ IRRLP 266_ LFYTI 271_ NLIIP 276_ CLLIS 281_ CLTVL 286_ VFYLP 291_ SDCGE 296_ KITLC 301_ ISVLL 306_ SLTVF 311_ LLLIT 316_ EIIPS 321_ TSLVI 326_ PLIGE 331_ YLLFT 336_ MIFVT 341_ LSIVI 346_ TVFVL 351_ NVHHR 356_ SPSTH 361_ TMPHW 366_ VRGAL 371_ LGCVP 376_ RWLLM 381_ NRPPP 386_ PVELC 391_ HPLRL 396_ KLSPS 401_ YHWLE 406_ SNVDA 411_ EEREV 416_ VVEEE 421_ DRWAC 426_ AGHVA 431_ PSVGT 436_ LCSHG 441_ HLHSG 446_ ASGPK 451_ AEALL 456_ QEGEL 461_ LLSPH 466_ MQKAL 471_ EGVHY 476_ IADHL 481_ RSEDA 486_ DSSVK 491_ EDWKY 496_ VAMVI 501_ DRIFL 506_ WLFII 511_ VCFLG 516_ TIGLF 521_LPPFL
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:18723036). CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence (PubMed:24467848, PubMed:27493220)