Neuronal acetylcholine receptor subunit alpha-6
1_MLTSK 6_ GQGFL 11_ HGGLC 16_ LWLCV 21_ FTPFF 26_ KGCVG 31_ CATEE 36_ RLFHK 41_ LFSHY 46_ NQFIR 51_ PVENV 56_ SDPVT 61_ VHFEV 66_ AITQL 71_ ANVDE 76_ VNQIM 81_ ETNLW 86_ LRHIW 91_ NDYKL 96_ RWDPM 101_ EYDGI 106_ ETLRV 111_ PADKI 116_ WKPDI 121_ VLYNN 126_ AVGDF 131_ QVEGK 136_ TKALL 141_ KYNGM 146_ ITWTP 151_ PAIFK 156_ SSCPM 161_ DITFF 166_ PFDHQ 171_ NCSLK 176_ FGSWT 181_ YDKAE 186_ IDLLI 191_ IGSKV 196_ DMNDF 201_ WENSE 206_ WEIID 211_ ASGYK 216_ HDIKY 221_ NCCEE 226_ IYTDI 231_ TYSFY 236_ IRRLP 241_ MFYTI 246_ NLIIP 251_ CLFIS 256_ FLTVL 261_ VFYLP 266_ SDCGE 271_ KVTLC 276_ ISVLL 281_ SLTVF 286_ LLVIT 291_ ETIPS 296_ TSLVV 301_ PLVGE 306_ YLLFT 311_ MIFVT 316_ LSIVV 321_ TVFVL 326_ NIHYR 331_ TPTTH 336_ TMPRW 341_ VKTVF 346_ LKLLP 351_ QVLLM 356_ RWPLD 361_ KTRGT 366_ GSDAV 371_ PRGLA 376_ RRPAK 381_ GKLAS 386_ HGEPR 391_ HLKEC 396_ FHCHK 401_ SNELA 406_ TSKRR 411_ LSHQP 416_ LQWVV 421_ ENSEH 426_ SPEVE 431_ DVINS 436_ VQFIA 441_ ENMKS 446_ HNETK 451_ EVEDD 456_ WKYVA 461_ MVVDR 466_ VFLWV 471_ FIIVC 476_ VFGTA 481_ GLFLQ 486_PLLGN
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). CHRNA6 forms pentameric channels with CHRNB2, CHRNB3 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system (PubMed:16835356). nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals