Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1)
1_MDFGS 6_ LETVV 11_ ANSAF 16_ IAARG 21_ SFDGS 26_ SSQPS 31_ RDKKY 36_ LAKLK 41_ LPPLS 46_ KCESL 51_ RDSLS 56_ LEFES 61_ VCLEQ 66_ PIGKK 71_ LFQQF 76_ LQSAE 81_ KHLPA 86_ LELWK 91_ DIEDY 96_ DTADN 101_ DLQPQ 106_ KAQTI 111_ LAQYL 116_ DPQAK 121_ LFCSF 126_ LDEGI 131_ VAKFK 136_ EGPVE 141_ IQDGL 146_ FQPLL 151_ QATLA 156_ HLGQA 161_ PFQEY 166_ LGSLY 171_ FLRFL 176_ QWKWL 181_ EAQPM 186_ GEDWF 191_ LDFRV 196_ LGKGG 201_ FGEVS 206_ ACQMK 211_ ATGKL 216_ YACKK 221_ LNKKR 226_ LKKRK 231_ GYQGA 236_ MVEKK 241_ ILMKV 246_ HSRFI 251_ VSLAY 256_ AFETK 261_ ADLCL 266_ VMTIM 271_ NGGDI 276_ RYHIY 281_ NVNEE 286_ NPGFP 291_ EPRAL 296_ FYTAQ 301_ IICGL 306_ EHLHQ 311_ RRIVY 316_ RDLKP 321_ ENVLL 326_ DNDGN 331_ VRISD 336_ LGLAV 341_ ELLDG 346_ QSKTK 351_ GYAGT 356_ PGFMA 361_ PELLQ 366_ GEEYD 371_ FSVDY 376_ FALGV 381_ TLYEM 386_ IAARG 391_ PFRAR 396_ GEKVE 401_ NKELK 406_ HRIIS 411_ EPVKY 416_ PDKFS 421_ QASKD 426_ FCEAL 431_ LEKDP 436_ EKRLG 441_ FRDET 446_ CDKLR 451_ AHPLF 456_ KDLNW 461_ RQLEA 466_ GMLMP 471_ PFIPD 476_ SKTVY 481_ AKDIQ 486_ DVGAF 491_ STVKG 496_ VAFDK 501_ TDTEF 506_ FQEFA 511_ TGNCP 516_ IPWQE 521_ EMIET 526_ GIFGE 531_ LNVWR 536_ SDGQM 541_ PDDMK 546_ GISGG 551_ SSSSS 556_KSGMC
1: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity)