ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)
1_MLARK 6_ SIIPE 11_ EYVLA 16_ RIAAE 21_ NLRKP 26_ RIRDR 31_ LPKAR 36_ FIAKS 41_ GACNL 46_ AHKNI 51_ REQGR 56_ FLQDI 61_ FTTLV 66_ DLKWR 71_ HTLVI 76_ FTMSF 81_ LCSWL 86_ LFAIM 91_ WWLVA 96_ FAHGD 101_ IYAYM 106_ EKSGM 111_ EKSGL 116_ ESTVC 121_ VTNVR 126_ SFTSA 131_ FLFSI 136_ EVQVT 141_ IGFGG 146_ RMMTE 151_ ECPLA 156_ ITVLI 161_ LQNIV 166_ GLIIN 171_ AVMLG 176_ CIFMK 181_ TAQAH 186_ RRAET 191_ LIFSR 196_ HAVIA 201_ VRNGK 206_ LCFMF 211_ RVGDL 216_ RKSMI 221_ ISASV 226_ RIQVV 231_ KKTTT 236_ PEGEV 241_ VPIHQ 246_ LDIPV 251_ DNPIE 256_ SNNIF 261_ LVAPL 266_ IICHV 271_ IDKRS 276_ PLYDI 281_ SATDL 286_ ANQDL 291_ EVIVI 296_ LEGVV 301_ ETTGI 306_ TTQAR 311_ TSYIA 316_ EEIQW 321_ GHRFV 326_ SIVTE 331_ EEGVY 336_ SVDYS 341_ KFGNT 346_ VKVAA 351_ PRCSA 356_ RELDE 361_ KPSIL 366_ IQTLQ 371_ KSELS 376_ HQNSL 381_ RKRNS 386_ MRRNN 391_ SMRRN 396_ NSIRR 401_ NNSSL 406_ MVPKV 411_ QFMTP 416_EGNQN
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (By similarity)