Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
1_MAMLP 6_ PPGPQ 11_ SFVHF 16_ TKQSL 21_ ALIEQ 26_ RIAER 31_ KSKEP 36_ KEEKK 41_ DDDEE 46_ APKPS 51_ SDLEA 56_ GKQLP 61_ FIYGD 66_ IPPGM 71_ VSEPL 76_ EDLDP 81_ YYADK 86_ KTFIV 91_ LNKGK 96_ TIFRF 101_ NATPA 106_ LYMLS 111_ PFSPL 116_ RRISI 121_ KILVH 126_ SLFSM 131_ LIMCT 136_ ILTNC 141_ IFMTM 146_ NNPPD 151_ WTKNV 156_ EYTFT 161_ GIYTF 166_ ESLVK 171_ ILARG 176_ FCVGE 181_ FTFLR 186_ DPWNW 191_ LDFVV 196_ IVFAY 201_ LTEFV 206_ NLGNV 211_ SALRT 216_ FRVLR 221_ ALKTI 226_ SVIPG 231_ LKTIV 236_ GALIQ 241_ SVKKL 246_ SDVMI 251_ LTVFC 256_ LSVFA 261_ LIGLQ 266_ LFMGN 271_ LKHKC 276_ FRNSL 281_ ENNET 286_ LESIM 291_ NTLES 296_ EEDFR 301_ KYFYY 306_ LEGSK 311_ DALLC 316_ GFSTD 321_ SGQCP 326_ EGYTC 331_ VKIGR 336_ NPDYG 341_ YTSFD 346_ TFSWA 351_ FLALF 356_ RLMTQ 361_ DYWEN 366_ LYQQT 371_ LRAAG 376_ KTYMI 381_ FFVVV 386_ IFLGS 391_ FYLIN 396_ LILAV 401_ VAMAY 406_ EEQNQ 411_ ANIEE 416_ AKQKE 421_ LEFQQ 426_ MLDRL 431_ KKEQE 436_ EAEAI 441_ AAAAA 446_ EYTSI 451_ RRSRI 456_ MGLSE 461_ SSSET 466_ SKLSS 471_ KSAKE 476_ RRNRR 481_ KKKNQ 486_ KKLSS 491_ GEEKG 496_ DAEKL 501_ SKSES 506_ EDSIR 511_ RKSFH 516_ LGVEG 521_ HRRAH 526_ EKRLS 531_ TPNQS 536_ PLSIR 541_ GSLFS 546_ ARRSS 551_ RTSLF 556_ SFKGR 561_ GRDIG 566_ SETEF 571_ ADDEH 576_ SIFGD 581_ NESRR 586_ GSLFV 591_ PHRPQ 596_ ERRSS 601_ NISQA 606_ SRSPP 611_ MLPVN 616_ GKMHS 621_ AVDCN 626_ GVVSL 631_ VDGRS 636_ ALMLP 641_ NGQLL 646_ PEVII 651_ DKATS 656_ DDSGT 661_ TNQIH 666_ KKRRC 671_ SSYLL 676_ SEDML 681_ NDPNL 686_ RQRAM 691_ SRASI 696_ LTNTV 701_ EELEE 706_ SRQKC 711_ PPWWY 716_ RFAHK 721_ FLIWN 726_ CSPYW 731_ IKFKK 736_ CIYFI 741_ VMDPF 746_ VDLAI 751_ TICIV 756_ LNTLF 761_ MAMEH 766_ HPMTE 771_ EFKNV 776_ LAIGN 781_ LVFTG 786_ IFAAE 791_ MVLKL 796_ IAMDP 801_ YEYFQ 806_ VGWNI 811_ FDSLI 816_ VTLSL 821_ VELFL 826_ ADVEG 831_ LSVLR 836_ SFRLL 841_ RVFKL 846_ AKSWP 851_ TLNML 856_ IKIIG 861_ NSVGA 866_ LGNLT 871_ LVLAI 876_ IVFIF 881_ AVVGM 886_ QLFGK 891_ SYKEC 896_ VCKIN 901_ DDCTL 906_ PRWHM 911_ NDFFH 916_ SFLIV 921_ FRVLC 926_ GEWIE 931_ TMWDC 936_ MEVAG 941_ QAMCL 946_ IVYMM 951_ VMVIG 956_ NLVVL 961_ NLFLA 966_ LLLSS 971_ FSSDN 976_ LTAIE 981_ EDPDA 986_ NNLQI 991_ AVTRI 996_ KKGIN 1001_ YVKQT 1006_ LREFI 1011_ LKAFS 1016_ KKPKI 1021_ SREIR 1026_ QAEDL 1031_ NTKKE 1036_ NYISN 1041_ HTLAE 1046_ MSKGH 1051_ NFLKE 1056_ KDKIS 1061_ GFGSS 1066_ VDKHL 1071_ MEDSD 1076_ GQSFI 1081_ HNPSL 1086_ TVTVP 1091_ IAPGE 1096_ SDLEN 1101_ MNAEE 1106_ LSSDS 1111_ DSEYS 1116_ KVRLN 1121_ RSSSS 1126_ ECSTV 1131_ DNPLP 1136_ GEGEE 1141_ AEAEP 1146_ MNSDE 1151_ PEACF 1156_ TDGCV 1161_ WRFSC 1166_ CQVNI 1171_ ESGKG 1176_ KIWWN 1181_ IRKTC 1186_ YKIVE 1191_ HSWFE 1196_ SFIVL 1201_ MILLS 1206_ SGALA 1211_ FEDIY 1216_ IERKK 1221_ TIKII 1226_ LEYAD 1231_ KIFTY 1236_ IFILE 1241_ MLLKW 1246_ IAYGY 1251_ KTYFT 1256_ NAWCW 1261_ LDFLI 1266_ VDVSL 1271_ VTLVA 1276_ NTLGY 1281_ SDLGP 1286_ IKSLR 1291_ TLRAL 1296_ RPLRA 1301_ LSRFE 1306_ GMRVV 1311_ VNALI 1316_ GAIPS 1321_ IMNVL 1326_ LVCLI 1331_ FWLIF 1336_ SIMGV 1341_ NLFAG 1346_ KFYEC 1351_ INTTD 1356_ GSRFP 1361_ ASQVP 1366_ NRSEC 1371_ FALMN 1376_ VSQNV 1381_ RWKNL 1386_ KVNFD 1391_ NVGLG 1396_ YLSLL 1401_ QVATF 1406_ KGWTI 1411_ IMYAA 1416_ VDSVN 1421_ VDKQP 1426_ KYEYS 1431_ LYMYI 1436_ YFVVF 1441_ IIFGS 1446_ FFTLN 1451_ LFIGV 1456_ IIDNF 1461_ NQQKK 1466_ KLGGQ 1471_ DIFMT 1476_ EEQKK 1481_ YYNAM 1486_ KKLGS 1491_ KKPQK 1496_ PIPRP 1501_ GNKIQ 1506_ GCIFD 1511_ LVTNQ 1516_ AFDIS 1521_ IMVLI 1526_ CLNMV 1531_ TMMVE 1536_ KEGQS 1541_ QHMTE 1546_ VLYWI 1551_ NVVFI 1556_ ILFTG 1561_ ECVLK 1566_ LISLR 1571_ HYYFT 1576_ VGWNI 1581_ FDFVV 1586_ VIISI 1591_ VGMFL 1596_ ADLIE 1601_ TYFVS 1606_ PTLFR 1611_ VIRLA 1616_ RIGRI 1621_ LRLVK 1626_ GAKGI 1631_ RTLLF 1636_ ALMMS 1641_ LPALF 1646_ NIGLL 1651_ LFLVM 1656_ FIYAI 1661_ FGMSN 1666_ FAYVK 1671_ KEDGI 1676_ NDMFN 1681_ FETFG 1686_ NSMIC 1691_ LFQIT 1696_ TSAGW 1701_ DGLLA 1706_ PILNS 1711_ KPPDC 1716_ DPKKV 1721_ HPGSS 1726_ VEGDC 1731_ GNPSV 1736_ GIFYF 1741_ VSYII 1746_ ISFLV 1751_ VVNMY 1756_ IAVIL 1761_ ENFSV 1766_ ATEES 1771_ TEPLS 1776_ EDDFE 1781_ MFYEV 1786_ WEKFD 1791_ PDATQ 1796_ FIEFS 1801_ KLSDF 1806_ AAALD 1811_ PPLLI 1816_ AKPNK 1821_ VQLIA 1826_ MDLPM 1831_ VSGDR 1836_ IHCLD 1841_ ILFAF 1846_ TKRVL 1851_ GESGE 1856_ MDSLR 1861_ SQMEE 1866_ RFMSA 1871_ NPSKV 1876_ SYEPI 1881_ TTTLK 1886_ RKQED 1891_ VSATV 1896_ IQRAY 1901_ RRYRL 1906_ RQNVK 1911_ NISSI 1916_ YIKDG 1921_ DRDDD 1926_ LLNKK 1931_ DMAFD 1936_ NVNEN 1941_ SSPEK 1946_ TDATS 1951_ STTSP 1956_ PSYDS 1961_ VTKPD 1966_ KEKYE 1971_ QDRTE 1976_ KEDKG 1981_KDSKE
1: Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784, PubMed:25240195, PubMed:26680203, PubMed:7720699). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784)