Protein FAM189A2 (Protein X123)
1_MILLV 6_ NLFVL 11_ LSVVC 16_ VLLNL 21_ AGFIL 26_ GCQGA 31_ QFVSS 36_ VPRCD 41_ LVDLG 46_ EGKIC 51_ FCCEE 56_ FQPAK 61_ CTDKE 66_ NALKL 71_ FPVQP 76_ CSAVH 81_ LLLKK 86_ VLFAL 91_ CALNA 96_ LTTTV 101_ CLVAA 106_ ALRYL 111_ QIFAT 116_ RRSCI 121_ DESQI 126_ SAEEA 131_ EDHGR 136_ IPDPD 141_ DFVPP 146_ VPPPS 151_ YFATF 156_ YSCTP 161_ RMNRR 166_ MVGPD 171_ VIPLP 176_ HIYGA 181_ RIKGV 186_ EVFCP 191_ LDPPP 196_ PYEAV 201_ VSQMD 206_ QEQGS 211_ SFQMS 216_ EGSEA 221_ AVIPL 226_ DLGCT 231_ QVTQD 236_ GDIPN 241_ IPAEE 246_ NASTS 251_ TPSST 256_ LVRPI 261_ RSRRA 266_ LPPLR 271_ TRSKS 276_ DPVLH 281_ PSEER 286_ AAPVL 291_ SCEAA 296_ TQTER 301_ RLDLA 306_ AVTLR 311_ RGLRS 316_ RASRC 321_ RPRSL 326_ IDYKS 331_ YMDTK 336_ LLVAR 341_ FLEQS 346_ SCTMT 351_ PDIHE 356_ LVENI 361_ KSVLK 366_ SDEEH 371_ MEEAI 376_ TSASF 381_ LEQIM 386_ APLQP 391_ STSRA 396_ HKLPS 401_ RRQPG 406_ LLHLQ 411_ SCGDL 416_ HTFTP 421_ AGRPR 426_ AERRP 431_ RRVEA 436_ ERPHS 441_LIGVI
1: Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway