V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)
1_MMAAM 6_ ATARV 11_ RMGPR 16_ CAQAL 21_ WRMPW 26_ LPVFL 31_ SLAAA 36_ AAAAA 41_ AEQQV 46_ PLVLW 51_ SSDRD 56_ LWAPA 61_ ADTHE 66_ GHITS 71_ DLQLS 76_ TYLDP 81_ ALELG 86_ PRNVL 91_ LFLQD 96_ KLSIE 101_ DFTAY 106_ GGVFG 111_ NKQDS 116_ AFSNL 121_ ENALD 126_ LAPSS 131_ LVLPA 136_ VDWYA 141_ VSTLT 146_ TYLQE 151_ KLGAS 156_ PLHVD 161_ LATLR 166_ ELKLN 171_ ASLPA 176_ LLLIR 181_ LPYTA 186_ SSGLM 191_ APREV 196_ LTGND 201_ EVIGQ 206_ VLSTL 211_ KSEDV 216_ PYTAA 221_ LTAVR 226_ PSRVA 231_ RDVAV 236_ VAGGL 241_ GRQLL 246_ QKQPV 251_ SPVIH 256_ PPVSY 261_ NDTAP 266_ RILFW 271_ AQNFS 276_ VAYKD 281_ QWEDL 286_ TPLTF 291_ GVQEL 296_ NLTGS 301_ FWNDS 306_ FARLS 311_ LTYER 316_ LFGTT 321_ VTFKF 326_ ILANR 331_ LYPVS 336_ ARHWF 341_ TMERL 346_ EVHSN 351_ GSVAY 356_ FNASQ 361_ VTGPS 366_ IYSFH 371_ CEYVS 376_ SLSKK 381_ GSLLV 386_ ARTQP 391_ SPWQM 396_ MLQDF 401_ QIQAF 406_ NVMGE 411_ QFSYA 416_ SDCAS 421_ FFSPG 426_ IWMGL 431_ LTSLF 436_ MLFIF 441_ TYGLH 446_ MILSL 451_ KTMDR 456_ FDDHK 461_GPTIS
1: Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (PubMed:33065002). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (PubMed:27231034). Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (PubMed:27231034). May play a role in the assembly of the V-type ATPase complex (Probable). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity)