Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)
1_MGTRD 6_ DEYDY 11_ LFKVV 16_ LIGDS 21_ GVGKS 26_ NLLSR 31_ FTRNE 36_ FNLES 41_ KSTIG 46_ VEFAT 51_ RSIQV 56_ DGKTI 61_ KAQIW 66_ DTAGQ 71_ ERYRA 76_ ITSAY 81_ YRGAV 86_ GALLV 91_ YDIAK 96_ HLTYE 101_ NVERW 106_ LKELR 111_ DHADS 116_ NIVIM 121_ LVGNK 126_ SDLRH 131_ LRAVP 136_ TDEAR 141_ AFAEK 146_ NNLSF 151_ IETSA 156_ LDSTN 161_ VEEAF 166_ KNILT 171_ EIYRI 176_ VSQKQ 181_ IADRA 186_ AHDES 191_ PGNNV 196_ VDISV 201_ PPTTD 206_ GQKPN 211_KLQCC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173)