Gene name: ZFHX3

Uniprot entry:

Q15911

Protein names:

Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)

Protein sequence:

1_MEGCD 6_ SPVVS 11_ GKDNG 16_ CGIPQ 21_ HQQWT 26_ ELNST 31_ HLPDK 36_ PSSME 41_ QSTGE 46_ SHGPL 51_ DSLRA 56_ PFNER 61_ LAEST 66_ ASAGP 71_ PSEPA 76_ SKEVT 81_ CNECS 86_ ASFAS 91_ LQTYM 96_ EHHCP 101_ SARPP 106_ PPLRE 111_ ESASD 116_ TGEEG 121_ DEESD 126_ VENLA 131_ GEIVY 136_ QPDGS 141_ AYIVE 146_ SLSQL 151_ TQGGG 156_ ACGSG 161_ SGSGP 166_ LPSLF 171_ LNSLP 176_ GAGGK 181_ QGDPS 186_ CAAPV 191_ YPQII 196_ NTFHI 201_ ASSFG 206_ KWFEG 211_ PDQAF 216_ PNTSA 221_ LAGLS 226_ PVLHS 231_ FRVFD 236_ VRHKS 241_ NKDYL 246_ NSDGS 251_ AKSSC 256_ VSKDV 261_ PNNVD 266_ LSKFD 271_ GFVLY 276_ GKRKP 281_ ILMCF 286_ LCKLS 291_ FGYVR 296_ SFVTH 301_ AVHDH 306_ RMTLS 311_ EDERK 316_ ILSNK 321_ NISAI 326_ IQGIG 331_ KDKEP 336_ LVSFL 341_ EPKNK 346_ NFQHP 351_ LVSTA 356_ NLIGP 361_ GHSFY 366_ GKFSG 371_ IRMEG 376_ EEALP 381_ AGSAA 386_ GPEQP 391_ QAGLL 396_ TPSTL 401_ LNLGG 406_ LTSSV 411_ LKTPI 416_ TSVPL 421_ GPLAS 426_ SPTKS 431_ SEGKD 436_ SGAAE 441_ GEKQE 446_ VGDGD 451_ CFSEK 456_ VEPAE 461_ EEAEE 466_ EEEEE 471_ EAEEE 476_ EEEEE 481_ EEEEE 486_ EEDEG 491_ CKGLF 496_ PSELD 501_ EELED 506_ RPHEE 511_ PGAAA 516_ GSSSK 521_ KDLAL 526_ SNQSI 531_ SNSPL 536_ MPNVL 541_ QTLSR 546_ GTAST 551_ SSNSA 556_ SSFVV 561_ FDGAN 566_ RRNRL 571_ SFNSE 576_ GVRAN 581_ VAEGG 586_ RRLDF 591_ ADESA 596_ NKDNA 601_ TAPEP 606_ NESTE 611_ GDDGG 616_ FVPHH 621_ QHAGS 626_ LCELG 631_ VGECP 636_ SGSGV 641_ ECPKC 646_ DTVLG 651_ SSRSL 656_ GGHMT 661_ MMHSR 666_ NSCKT 671_ LKCPK 676_ CNWHY 681_ KYQQT 686_ LEAHM 691_ KEKHP 696_ EPGGS 701_ CVYCK 706_ SGQPH 711_ PRLAR 716_ GESYT 721_ CGYKP 726_ FRCEV 731_ CNYST 736_ TTKGN 741_ LSIHM 746_ QSDKH 751_ LNNMQ 756_ NLQNG 761_ GGEQV 766_ FSHTA 771_ GAAAA 776_ AVAAA 781_ AAAAN 786_ ISSSC 791_ GAPSP 796_ TKPKT 801_ KPTWR 806_ CEVCD 811_ YETNV 816_ ARNLR 821_ IHMTS 826_ EKHMH 831_ NMMLL 836_ QQNMT 841_ QIQHN 846_ RHLGL 851_ GSLPS 856_ PAEAE 861_ LYQYY 866_ LAQNM 871_ NLPNL 876_ KMDSA 881_ ASDAQ 886_ FMMSG 891_ FQLDP 896_ AGPMA 901_ AMTPA 906_ LVGGE 911_ IPLDM 916_ RLGGG 921_ QLVSE 926_ ELMNL 931_ GESFI 936_ QTNDP 941_ SLKLF 946_ QCAVC 951_ NKFTT 956_ DNLDM 961_ LGLHM 966_ NVERS 971_ LSEDE 976_ WKAVM 981_ GDSYQ 986_ CKLCR 991_ YNTQL 996_ KANFQ 1001_ LHCKT 1006_ DKHVQ 1011_ KYQLV 1016_ AHIKE 1021_ GGKAN 1026_ EWRLK 1031_ CVAIG 1036_ NPVHL 1041_ KCNAC 1046_ DYYTN 1051_ SLEKL 1056_ RLHTV 1061_ NSRHE 1066_ ASLKL 1071_ YKHLQ 1076_ QHESG 1081_ VEGES 1086_ CYYHC 1091_ VLCNY 1096_ STKAK 1101_ LNLIQ 1106_ HVRSM 1111_ KHQRS 1116_ ESLRK 1121_ LQRLQ 1126_ KGLPE 1131_ EDEDL 1136_ GQIFT 1141_ IRRCP 1146_ STDPE 1151_ EAIED 1156_ VEGPS 1161_ ETAAD 1166_ PEELA 1171_ KDQEG 1176_ GASSS 1181_ QAEKE 1186_ LTDSP 1191_ ATSKR 1196_ ISFPG 1201_ SSESP 1206_ LSSKR 1211_ PKTAE 1216_ EIKPE 1221_ QMYQC 1226_ PYCKY 1231_ SNADV 1236_ NRLRV 1241_ HAMTQ 1246_ HSVQP 1251_ MLRCP 1256_ LCQDM 1261_ LNNKI 1266_ HLQLH 1271_ LTHLH 1276_ SVAPD 1281_ CVEKL 1286_ IMTVT 1291_ TPEMV 1296_ MPSSM 1301_ FLPAA 1306_ VPDRD 1311_ GNSNL 1316_ EEAGK 1321_ QPETS 1326_ EDLGK 1331_ NILPS 1336_ ASTEQ 1341_ SGDLK 1346_ PSPAD 1351_ PGSVR 1356_ EDSGF 1361_ ICWKK 1366_ GCNQV 1371_ FKTSA 1376_ ALQTH 1381_ FNEVH 1386_ AKRPQ 1391_ LPVSD 1396_ RHVYK 1401_ YRCNQ 1406_ CSLAF 1411_ KTIEK 1416_ LQLHS 1421_ QYHVI 1426_ RAATM 1431_ CCLCQ 1436_ RSFRT 1441_ FQALK 1446_ KHLET 1451_ SHLEL 1456_ SEADI 1461_ QQLYG 1466_ GLLAN 1471_ GDLLA 1476_ MGDPT 1481_ LAEDH 1486_ TIIVE 1491_ EDKEE 1496_ ESDLE 1501_ DKQSP 1506_ TGSDS 1511_ GSVQE 1516_ DSGSE 1521_ PKRAL 1526_ PFRKG 1531_ PNFTM 1536_ EKFLD 1541_ PSRPY 1546_ KCTVC 1551_ KESFT 1556_ QKNIL 1561_ LVHYN 1566_ SVSHL 1571_ HKLKR 1576_ ALQES 1581_ ATGQP 1586_ EPTSS 1591_ PDNKP 1596_ FKCNT 1601_ CNVAY 1606_ SQSST 1611_ LEIHM 1616_ RSVLH 1621_ QTKAR 1626_ AAKLE 1631_ AASGS 1636_ SNGTG 1641_ NSSSI 1646_ SLSSS 1651_ TPSPV 1656_ STSGS 1661_ NTFTT 1666_ SNPSS 1671_ AGIAP 1676_ SSNLL 1681_ SQVPT 1686_ ESVGM 1691_ PPLGN 1696_ PIGAN 1701_ IASPS 1706_ EPKEA 1711_ NRKKL 1716_ ADMIA 1721_ SRQQQ 1726_ QQQQQ 1731_ QQQQQ 1736_ QQQQQ 1741_ QAQTL 1746_ AQAQA 1751_ QVQAH 1756_ LQQEL 1761_ QQQAA 1766_ LIQSQ 1771_ LFNPT 1776_ LLPHF 1781_ PMTTE 1786_ TLLQL 1791_ QQQQH 1796_ LLFPF 1801_ YIPSA 1806_ EFQLN 1811_ PEVSL 1816_ PVTSG 1821_ ALTLT 1826_ GTGPG 1831_ LLEDL 1836_ KAQVQ 1841_ VPQQS 1846_ HQQIL 1851_ PQQQQ 1856_ NQLSI 1861_ AQSHS 1866_ ALLQP 1871_ SQHPE 1876_ KKNKL 1881_ VIKEK 1886_ EKESQ 1891_ RERDS 1896_ AEGGE 1901_ GNTGP 1906_ KETLP 1911_ DALKA 1916_ KEKKE 1921_ LAPGG 1926_ GSEPS 1931_ MLPPR 1936_ IASDA 1941_ RGNAT 1946_ KALLE 1951_ NFGFE 1956_ LVIQY 1961_ NENKQ 1966_ KVQKK 1971_ NGKTD 1976_ QGENL 1981_ EKLEC 1986_ DSCGK 1991_ LFSNI 1996_ LILKS 2001_ HQEHV 2006_ HQNYF 2011_ PFKQL 2016_ ERFAK 2021_ QYRDH 2026_ YDKLY 2031_ PLRPQ 2036_ TPEPP 2041_ PPPPP 2046_ PPPPP 2051_ LPAAP 2056_ PQPAS 2061_ TPAIP 2066_ ASAPP 2071_ ITSPT 2076_ IAPAQ 2081_ PSVPL 2086_ TQLSM 2091_ PMELP 2096_ IFSPL 2101_ MMQTM 2106_ PLQTL 2111_ PAQLP 2116_ PQLGP 2121_ VEPLP 2126_ ADLAQ 2131_ LYQHQ 2136_ LNPTL 2141_ LQQQN 2146_ KRPRT 2151_ RITDD 2156_ QLRVL 2161_ RQYFD 2166_ INNSP 2171_ SEEQI 2176_ KEMAD 2181_ KSGLP 2186_ QKVIK 2191_ HWFRN 2196_ TLFKE 2201_ RQRNK 2206_ DSPYN 2211_ FSNPP 2216_ ITSLE 2221_ ELKID 2226_ SRPPS 2231_ PEPPK 2236_ QEYWG 2241_ SKRSS 2246_ RTRFT 2251_ DYQLR 2256_ VLQDF 2261_ FDANA 2266_ YPKDD 2271_ EFEQL 2276_ SNLLN 2281_ LPTRV 2286_ IVVWF 2291_ QNARQ 2296_ KARKN 2301_ YENQG 2306_ EGKDG 2311_ ERREL 2316_ TNDRY 2321_ IRTSN 2326_ LNYQC 2331_ KKCSL 2336_ VFQRI 2341_ FDLIK 2346_ HQKKL 2351_ CYKDE 2356_ DEEGQ 2361_ DDSQN 2366_ EDSMD 2371_ AMEIL 2376_ TPTSS 2381_ SCSTP 2386_ MPSQA 2391_ YSAPA 2396_ PSANN 2401_ TASSA 2406_ FLQLT 2411_ AEAEE 2416_ LATFN 2421_ SKTEA 2426_ GDEKP 2431_ KLAEA 2436_ PSAQP 2441_ NQTQE 2446_ KQGQP 2451_ KPELQ 2456_ QQEQP 2461_ EQKTN 2466_ TPQQK 2471_ LPQLV 2476_ SLPSL 2481_ PQPPP 2486_ QAPPP 2491_ QCPLP 2496_ QSSPS 2501_ PSQLS 2506_ HLPLK 2511_ PLHTS 2516_ TPQQL 2521_ ANLPP 2526_ QLIPY 2531_ QCDQC 2536_ KLAFP 2541_ SFEHW 2546_ QEHQQ 2551_ LHFLS 2556_ AQNQF 2561_ IHPQF 2566_ LDRSL 2571_ DMPFM 2576_ LFDPS 2581_ NPLLA 2586_ SQLLS 2591_ GAIPQ 2596_ IPASS 2601_ ATSPS 2606_ TPTST 2611_ MNTLK 2616_ RKLEE 2621_ KASAS 2626_ PGEND 2631_ SGTGG 2636_ EEPQR 2641_ DKRLR 2646_ TTITP 2651_ EQLEI 2656_ LYQKY 2661_ LLDSN 2666_ PTRKM 2671_ LDHIA 2676_ HEVGL 2681_ KKRVV 2686_ QVWFQ 2691_ NTRAR 2696_ ERKGQ 2701_ FRAVG 2706_ PAQAH 2711_ RRCPF 2716_ CRALF 2721_ KAKTA 2726_ LEAHI 2731_ RSRHW 2736_ HEAKR 2741_ AGYNL 2746_ TLSAM 2751_ LLDCD 2756_ GGLQM 2761_ KGDIF 2766_ DGTSF 2771_ SHLPP 2776_ SSSDG 2781_ QGVPL 2786_ SPVSK 2791_ TMELS 2796_ PRTLL 2801_ SPSSI 2806_ KVEGI 2811_ EDFES 2816_ PSMSS 2821_ VNLNF 2826_ DQTKL 2831_ DNDDC 2836_ SSVNT 2841_ AITDT 2846_ TTGDE 2851_ GNADN 2856_ DSATG 2861_ IATET 2866_ KSSSA 2871_ PNEGL 2876_ TKAAM 2881_ MAMSE 2886_ YEDRL 2891_ SSGLV 2896_ SPAPS 2901_ FYSKE 2906_ YDNEG 2911_ TVDYS 2916_ ETSSL 2921_ ADPCS 2926_ PSPGA 2931_ SGSAG 2936_ KSGDS 2941_ GDRPG 2946_ QKRFR 2951_ TQMTN 2956_ LQLKV 2961_ LKSCF 2966_ NDYRT 2971_ PTMLE 2976_ CEVLG 2981_ NDIGL 2986_ PKRVV 2991_ QVWFQ 2996_ NARAK 3001_ EKKSK 3006_ LSMAK 3011_ HFGIN 3016_ QTSYE 3021_ GPKTE 3026_ CTLCG 3031_ IKYSA 3036_ RLSVR 3041_ DHIFS 3046_ QQHIS 3051_ KVKDT 3056_ IGSQL 3061_ DKEKE 3066_ YFDPA 3071_ TVRQL 3076_ MAQQE 3081_ LDRIK 3086_ KANEV 3091_ LGLAA 3096_ QQQGM 3101_ FDNTP 3106_ LQALN 3111_ LPTAY 3116_ PALQG 3121_ IPPVL 3126_ LPGLN 3131_ SPSLP 3136_ GFTPS 3141_ NTALT 3146_ SPKPN 3151_ LMGLP 3156_ STTVP 3161_ SPGLP 3166_ TSGLP 3171_ NKPSS 3176_ ASLSS 3181_ PTPAQ 3186_ ATMAM 3191_ GPQQP 3196_ PQQQQ 3201_ QQQQP 3206_ QVQQP 3211_ PPPPA 3216_ AQPPP 3221_ TPQLP 3226_ LQQQQ 3231_ QRKDK 3236_ DSEKV 3241_ KEKEK 3246_ AHKGK 3251_ GEPLP 3256_ VPKKE 3261_ KGEAP 3266_ TATAA 3271_ TISAP 3276_ LPTME 3281_ YAVDP 3286_ AQLQA 3291_ LQAAL 3296_ TSDPT 3301_ ALLTS 3306_ QFLPY 3311_ FVPGF 3316_ SPYYA 3321_ PQIPG 3326_ ALQSG 3331_ YLQPM 3336_ YGMEG 3341_ LFPYS 3346_ PALSQ 3351_ ALMGL 3356_ SPGSL 3361_ LQQYQ 3366_ QYQQS 3371_ LQEAI 3376_ QQQQQ 3381_ RQLQQ 3386_ QQQQK 3391_ VQQQQ 3396_ PKASQ 3401_ TPVPP 3406_ GAPSP 3411_ DKDPA 3416_ KESPK 3421_ PEEQK 3426_ NTPRE 3431_ VSPLL 3436_ PKLPE 3441_ EPEAE 3446_ SKSAD 3451_ SLYDP 3456_ FIVPK 3461_ VQYKL 3466_ VCRKC 3471_ QAGFS 3476_ DEEAA 3481_ RSHLK 3486_ SLCFF 3491_ GQSVV 3496_ NLQEM 3501_ VLHVP 3506_ TGGGG 3511_ GGSGG 3516_ GGGGG 3521_ GGGGG 3526_ GGSYH 3531_ CLACE 3536_ SALCG 3541_ EEALS 3546_ QHLES 3551_ ALHKH 3556_ RTITR 3561_ AARNA 3566_ KEHPS 3571_ LLPHS 3576_ ACFPD 3581_ PSTAS 3586_ TSQSA 3591_ AHSND 3596_ SPPPP 3601_ SAAAP 3606_ SSASP 3611_ HASRK 3616_ SWPQV 3621_ VSRAS 3626_ AAKPP 3631_ SFPPL 3636_ SSSST 3641_ VTSSS 3646_ CSTSG 3651_ VQPSM 3656_ PTDDY 3661_ SEESD 3666_ TDLSQ 3671_ KSDGP 3676_ ASPVE 3681_ GPKDP 3686_ SCPKD 3691_ SGLTS 3696_VGTDT

Protein annotations

Protein functions:

1: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010)