Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1)
1_MLLDA 6_ GPQYP 11_ AIGVT 16_ TFGAS 21_ RHHSA 26_ GDVAE 31_ RDVGL 36_ GINPF 41_ ADGMG 46_ AFKLN 51_ PSSHE 56_ LASAG 61_ QTAFT 66_ SQAPG 71_ YAAAA 76_ ALGHH 81_ HHPGH 86_ VGSYS 91_ SAAFN 96_ STRDF 101_ LFRNR 106_ GFGDA 111_ AAAAS 116_ AQHSL 121_ FAASA 126_ GGFGG 131_ PHGHT 136_ DAAGH 141_ LLFPG 146_ LHEQA 151_ AGHAS 156_ PNVVN 161_ GQMRL 166_ GFSGD 171_ MYPRP 176_ EQYGQ 181_ VTSPR 186_ SEHYA 191_ APQLH 196_ GYGPM 201_ NVNMA 206_ AHHGA 211_ GAFFR 216_ YMRQP 221_ IKQEL 226_ ICKWI 231_ EPEQL 236_ ANPKK 241_ SCNKT 246_ FSTMH 251_ ELVTH 256_ VTVEH 261_ VGGPE 266_ QSNHI 271_ CFWEE 276_ CPREG 281_ KPFKA 286_ KYKLV 291_ NHIRV 296_ HTGEK 301_ PFPCP 306_ FPGCG 311_ KVFAR 316_ SENLK 321_ IHKRT 326_ HTGEK 331_ PFKCE 336_ FEGCD 341_ RRFAN 346_ SSDRK 351_ KHMHV 356_ HTSDK 361_ PYLCK 366_ MCDKS 371_ YTHPS 376_ SLRKH 381_ MKVHE 386_ SSSQG 391_ SQPSP 396_ AASSG 401_ YESST 406_ PPTIV 411_ SPSTD 416_ NPTTS 421_ SLSPS 426_ SSAVH 431_ HTAGH 436_ SALSS 441_NFNEW
1: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)