Beta-synuclein
1_MDVFM 6_ KGLSM 11_ AKEGV 16_ VAAAE 21_ KTKQG 26_ VTEAA 31_ EKTKE 36_ GVLYV 41_ GSKTR 46_ EGVVQ 51_ GVASV 56_ AEKTK 61_ EQASH 66_ LGGAV 71_ FSGAG 76_ NIAAA 81_ TGLVK 86_ REEFP 91_ TDLKP 96_ EEVAQ 101_ EAAEE 106_ PLIEP 111_ LMEPE 116_ GESYE 121_ DPPQE 126_EYQEY
1: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease