Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
1_MTTSG 6_ ALFPS 11_ LVPGS 16_ RGASN 21_ KYLVE 26_ FRAGK 31_ MSLKG 36_ TTVTP 41_ DKRKG 46_ LVYIQ 51_ QTDDS 56_ LIHFC 61_ WKDRT 66_ SGNVE 71_ DDLII 76_ FPDDC 81_ EFKRV 86_ PQCPS 91_ GRVYV 96_ LKFKA 101_ GSKRL 106_ FFWMQ 111_ EPKTD 116_ QDEEH 121_ CRKVN 126_ EYLNN 131_ PPMPG 136_ ALGAS 141_ GSSGH 146_ ELSAL 151_ GGEGG 156_ LQSLL 161_ GNMSH 166_ SQLMQ 171_ LIGPA 176_ GLGGL 181_ GGLGA 186_ LTGPG 191_ LASLL 196_ GSSGP 201_ PGSSS 206_ SSSSR 211_ SQSAA 216_ VTPSS 221_ TTSST 226_ RATPA 231_ PSAPA 236_ AASAT 241_ SPSPA 246_ PSSGN 251_ GASTA 256_ ASPTQ 261_ PIQLS 266_ DLQSI 271_ LATMN 276_ VPAGP 281_ AGGQQ 286_ VDLAS 291_ VLTPE 296_ IMAPI 301_ LANAD 306_ VQERL 311_ LPYLP 316_ SGESL 321_ PQTAD 326_ EIQNT 331_ LTSPQ 336_ FQQAL 341_ GMFSA 346_ ALASG 351_ QLGPL 356_ MCQFG 361_ LPAEA 366_ VEAAN 371_ KGDVE 376_ AFAKA 381_ MQNNA 386_ KPEQK 391_ EGDTK 396_ DKKDE 401_EEDMS
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541)