Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]
1_MQRDF 6_ RWLWV 11_ YEIGY 16_ AADNS 21_ RTLNV 26_ DSTAM 31_ TLPMS 36_ DPTAW 41_ ATAMN 46_ NLGMA 51_ PLGIA 56_ GQPIL 61_ PDFDP 66_ ALGMM 71_ TGIPP 76_ ITPMM 81_ PGLGI 86_ VPPPI 91_ PPDMP 96_ VVKEI 101_ IHCKS 106_ CTLFP 111_ PNPNL 116_ PPPAT 121_ RERPP 126_ GCKTV 131_ FVGGL 136_ PENGT 141_ EQIIV 146_ EVFEQ 151_ CGEII 156_ AIRKS 161_ KKNFC 166_ HIRFA 171_ EEYMV 176_ DKALY 181_ LSGYR 186_ IRLGS 191_ STDKK 196_ DTGRL 201_ HVDFA 206_ QARDD 211_ LYEWE 216_ CKQRM 221_ LAREE 226_ RHRRR 231_ MEEER 236_ LRPPS 241_ PPPVV 246_ HYSDH 251_ ECSIV 256_ AEKLK 261_ DDSKF 266_ SEAVQ 271_ TLLTW 276_ IERGE 281_ VNRRS 286_ ANNFY 291_ SMIQS 296_ ANSHV 301_ RRLVN 306_ EKAAH 311_ EKDME 316_ EAKEK 321_ FKQAL 326_ SGILI 331_ QFEQI 336_ VAVYH 341_ SASKQ 346_ KAWDH 351_ FTKAQ 356_ RKNIS 361_ VWCKQ 366_ AEEIR 371_ NIHND 376_ ELMGI 381_ RREEE 386_ MEMSD 391_ DEIEE 396_ MTETK 401_ ETEES 406_ ALVSQ 411_ AEALK 416_ EENDS 421_ LRWQL 426_ DAYRN 431_ EVELL 436_ KQEQG 441_ KVHRE 446_ DDPNK 451_ EQQLK 456_ LLQQA 461_ LQGMQ 466_ QHLLK 471_ VQEEY 476_ KKKEA 481_ ELEKL 486_ KDDKL 491_ QVEKM 496_ LENLK 501_ EKESC 506_ ASRLC 511_ ASNQD 516_ SEYPL 521_ EKTMN 526_ SSPIK 531_ SEREA 536_ LLVGI 541_ ISTFL 546_ HVHPF 551_ GASIE 556_ YICSY 561_ LHRLD 566_ NKICT 571_ SDVEC 576_ LMGRL 581_ QHTFK 586_ QEMTG 591_ VGASL 596_ EKRWK 601_FCGFE
1: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock