UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)]
1_MNIND 6_ LKLTL 11_ SKAGQ 16_ EHLLR 21_ FWNEL 26_ EEAQQ 31_ VELYA 36_ ELQAM 41_ NFEEL 46_ NFFFQ 51_ KAIEG 56_ FNQSS 61_ HQKNV 66_ DARME 71_ PVPRE 76_ VLGSA 81_ TRDQD 86_ QLQAW 91_ ESEGL 96_ FQISQ 101_ NKVAV 106_ LLLAG 111_ GQGTR 116_ LGVAY 121_ PKGMY 126_ DVGLP 131_ SRKTL 136_ FQIQA 141_ ERILK 146_ LQQVA 151_ EKYYG 156_ NKCII 161_ PWYIM 166_ TSGRT 171_ MESTK 176_ EFFTK 181_ HKYFG 186_ LKKEN 191_ VIFFQ 196_ QGMLP 201_ AMSFD 206_ GKIIL 211_ EEKNK 216_ VSMAP 221_ DGNGG 226_ LYRAL 231_ AAQNI 236_ VEDME 241_ QRGIW 246_ SIHVY 251_ CVDNI 256_ LVKVA 261_ DPRFI 266_ GFCIQ 271_ KGADC 276_ GAKVV 281_ EKTNP 286_ TEPVG 291_ VVCRV 296_ DGVYQ 301_ VVEYS 306_ EISLA 311_ TAQKR 316_ SSDGR 321_ LLFNA 326_ GNIAN 331_ HFFTV 336_ PFLRD 341_ VVNVY 346_ EPQLQ 351_ HHVAQ 356_ KKIPY 361_ VDTQG 366_ QLIKP 371_ DKPNG 376_ IKMEK 381_ FVFDI 386_ FQFAK 391_ KFVVY 396_ EVLRE 401_ DEFSP 406_ LKNAD 411_ SQNGK 416_ DNPTT 421_ ARHAL 426_ MSLHH 431_ CWVLN 436_ AGGHF 441_ IDENG 446_ SRLPA 451_ IPRSA 456_ TNGKS 461_ ETITA 466_ DVNHN 471_ LKDAN 476_ DVPIQ 481_ CEISP 486_ LISYA 491_ GEGLE 496_ SYVAD 501_ KEFHA 506_ PLIID 511_ ENGVH 516_ELVKN
1: Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579)
2: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P)
3: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)