Transcription factor E2F4 (E2F-4)
1_MAEAG 6_ PQAPP 11_ PPGTP 16_ SRHEK 21_ SLGLL 26_ TTKFV 31_ SLLQE 36_ AKDGV 41_ LDLKL 46_ AADTL 51_ AVRQK 56_ RRIYD 61_ ITNVL 66_ EGIGL 71_ IEKKS 76_ KNSIQ 81_ WKGVG 86_ PGCNT 91_ REIAD 96_ KLIEL 101_ KAEIE 106_ ELQQR 111_ EQELD 116_ QHKVW 121_ VQQSI 126_ RNVTE 131_ DVQNS 136_ CLAYV 141_ THEDI 146_ CRCFA 151_ GDTLL 156_ AIRAP 161_ SGTSL 166_ EVPIP 171_ EGLNG 176_ QKKYQ 181_ IHLKS 186_ VSGPI 191_ EVLLV 196_ NKEAW 201_ SSPPV 206_ AVPVP 211_ PPEDL 216_ LQSPS 221_ AVSTP 226_ PPLPK 231_ PALAQ 236_ SQEAS 241_ RPNSP 246_ QLTPT 251_ AVPGS 256_ AEVQG 261_ MAGPA 266_ AEITV 271_ SGGPG 276_ TDSKD 281_ SGELS 286_ SLPLG 291_ PTTLD 296_ TRPLQ 301_ SSALL 306_ DSSSS 311_ SSSSS 316_ SSSSN 321_ SNSSS 326_ SSGPN 331_ PSTSF 336_ EPIKA 341_ DPTGV 346_ LELPK 351_ ELSEI 356_ FDPTR 361_ ECMSS 366_ ELLEE 371_ LMSSE 376_ VFAPL 381_ LRLSP 386_ PPGDH 391_ DYIYN 396_ LDESE 401_ GVCDL 406_FDVPV
1: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis