Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (Cyclic nucleotide-gated channel alpha-2) (CNG channel alpha-2) (CNG-2) (CNG2)
1_MTEKT 6_ NGVKS 11_ SPANN 16_ HNHHA 21_ PPAIK 26_ ANGKD 31_ DHRTS 36_ SRPHS 41_ AADDD 46_ TSSEL 51_ QRLAD 56_ VDAPQ 61_ QGRSG 66_ FRRIV 71_ RLVGI 76_ IREWA 81_ NKNFR 86_ EEEPR 91_ PDSFL 96_ ERFRG 101_ PELQT 106_ VTTQE 111_ GDGKG 116_ DKDGE 121_ DKGTK 126_ KKFEL 131_ FVLDP 136_ AGDWY 141_ YCWLF 146_ VIAMP 151_ VLYNW 156_ CLLVA 161_ RACFS 166_ DLQKG 171_ YYLVW 176_ LVLDY 181_ VSDVV 186_ YIADL 191_ FIRLR 196_ TGFLE 201_ QGLLV 206_ KDTKK 211_ LRDNY 216_ IHTLQ 221_ FKLDV 226_ ASIIP 231_ TDLIY 236_ FAVDI 241_ HSPEV 246_ RFNRL 251_ LHFAR 256_ MFEFF 261_ DRTET 266_ RTNYP 271_ NIFRI 276_ SNLVL 281_ YILVI 286_ IHWNA 291_ CIYYA 296_ ISKSI 301_ GFGVD 306_ TWVYP 311_ NITDP 316_ EYGYL 321_ AREYI 326_ YCLYW 331_ STLTL 336_ TTIGE 341_ TPPPV 346_ KDEEY 351_ LFVIF 356_ DFLIG 361_ VLIFA 366_ TIVGN 371_ VGSMI 376_ SNMNA 381_ TRAEF 386_ QAKID 391_ AVKHY 396_ MQFRK 401_ VSKGM 406_ EAKVI 411_ RWFDY 416_ LWTNK 421_ KTVDE 426_ REILK 431_ NLPAK 436_ LRAEI 441_ AINVH 446_ LSTLK 451_ KVRIF 456_ HDCEA 461_ GLLVE 466_ LVLKL 471_ RPQVF 476_ SPGDY 481_ ICRKG 486_ DIGKE 491_ MYIIK 496_ EGKLA 501_ VVADD 506_ GVTQY 511_ ALLSA 516_ GSCFG 521_ EISIL 526_ NIKGS 531_ KMGNR 536_ RTANI 541_ RSLGY 546_ SDLFC 551_ LSKDD 556_ LMEAV 561_ TEYPD 566_ AKKVL 571_ EERGR 576_ EILMK 581_ EGLLD 586_ ENEVA 591_ TSMEV 596_ DVQEK 601_ LGQLE 606_ TNMET 611_ LYTRF 616_ GRLLA 621_ EYTGA 626_ QQKLK 631_ QRITV 636_ LETKM 641_ KQNNE 646_ DDYLS 651_ DGMNS 656_PELAA
1: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations